MYH14 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Tucatinib (SCHEMBL1193050)	1.00	1/20
SCHEMBL12872734	0.84	1/20
SCHEMBL12888149	0.84	1/20
SCHEMBL1193042	0.82	1/20
SCHEMBL17838072	0.82	1/20
SCHEMBL1193003	0.80	1/20
SCHEMBL20164910	0.79	1/20
SCHEMBL12888270	0.78	1/20
SCHEMBL1192953	0.76	1/20
SCHEMBL1192394	0.76	1/20
SCHEMBL1194271	0.76	1/20
SCHEMBL12888199	0.74	1/20
SCHEMBL20629889	0.74	1/20
SCHEMBL1192637	0.73	1/20
SCHEMBL1192639	0.73	1/20
SCHEMBL23777558	0.72	1/20
SCHEMBL19236057	0.72	1/20
SCHEMBL1192772	0.71	1/20
SCHEMBL17838068	0.71	1/20
SCHEMBL24167354	0.71	1/20

Clinical trials — most relevant to MYH14 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Lifestyle and Pharmacological Interventions in Hypertrophic Cardiomyopathy	PHASE2/PHASE3	COMPLETED
Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem	PHASE2/PHASE3	COMPLETED
Empagliflozin in Hypertrophic Cardiomyopathy	PHASE3	ACTIVE_NOT_RECRUITING
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy	PHASE2	COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability	PHASE1	COMPLETED
Transcutaneous Functional Magnetic Muscle Stimulation in Critically Ill	nan	UNKNOWN
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium	nan	COMPLETED
Predictive Factors and Consequences of Myocardial Fibrosis in Hypertrophic Cardiomyopathy	nan	UNKNOWN
Phenotypic and Genotypic Identification and Characterization of MYH9-related Constitutional Thrombocytopenia	nan	COMPLETED
Chronic Muscle Disuse in the Elderly	nan	COMPLETED
Improvement of DIAgnostic and Phenotype-genotype Correlation Studies in Patients With MYOpathy Suspected of TITinopathy	nan	UNKNOWN
Evaluation of Albuminuria HIV-Infected Patients	nan	COMPLETED
Regulation of Muscle Protein Phenotype in Humans With Obesity	nan	COMPLETED
Molecular and Genetic Studies of Congenital Myopathies	nan	RECRUITING
Characteristics of Nondystrophic Myotonias	nan	COMPLETED
The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies.	nan	RECRUITING
Natural History Study for Patients With Nemaline Myopathy in Belgium	nan	NOT_YET_RECRUITING
Phenotype - Genotype Correlation in a Sample of Egyptian Patients With Congenital Myopathies and Congenital Muscular Dystrophies	nan	RECRUITING
Genetic Analysis of African-Americans With High Blood Pressure	nan	COMPLETED
New Diagnostic Strategy in Hypertrophic Cardiomyopathy	nan	UNKNOWN
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome	nan	ACTIVE_NOT_RECRUITING
Recovery From 50 Eccentric Biceps Curls in Young, Untrained Men and Women	nan	COMPLETED
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Exploring Novel Biomarkers of ICU-AW in Mechanically Ventilated Children at the Molecular Level	nan	ENROLLING_BY_INVITATION
Transcutaneous Electrical Diaphragmatic Stimulation in Critically Ill Elderly Patients	nan	UNKNOWN
Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse	nan	COMPLETED
3D-Microscopic Muscle Architecture in Cerebral Palsy	nan	RECRUITING
Irisin Hormone as a Novel Diagnostic Marker for Detection and Progression of Diabetic Nephrophathy Patients	nan	NOT_YET_RECRUITING
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a MYH14 binder may also engage these)

Protein	Name	Similarity
Q6URW6	—	1.000	Q6URW6 →
P47807	—	0.990	P47807 →
Q9WTI7	—	0.981	Q9WTI7 →
O00159	—	0.980	O00159 →
Q27966	—	0.979	Q27966 →
Q63355	—	0.977	Q63355 →
Q9JLT0	—	0.974	Q9JLT0 →
A7E2Y1	—	0.974	A7E2Y1 →
P35749	—	0.974	P35749 →
MYH10	Myosin-10	0.973	landscape →
O08638	—	0.972	O08638 →
A2AQP0	—	0.972	A2AQP0 →
Q9UBC5	—	0.972	Q9UBC5 →
Q258K2	—	0.971	Q258K2 →
Q8VDD5	—	0.971	Q8VDD5 →
Q27991	—	0.971	Q27991 →
P14105	—	0.971	P14105 →
Q61879	—	0.969	Q61879 →
Q62774	—	0.969	Q62774 →
MYH9	Myosin-9	0.969	landscape →
P35748	—	0.969	P35748 →
O88329	—	0.968	O88329 →
P70248	—	0.967	P70248 →
Q5SV80	—	0.967	Q5SV80 →
Q5ZLA6	—	0.967	Q5ZLA6 →
P10568	—	0.966	P10568 →
Q62812	—	0.966	Q62812 →
P10587	—	0.965	P10587 →
Q96H55	—	0.964	Q96H55 →
PLCD1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	0.962	landscape →