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NDUFA8

NADH dehydrogenase [ubiquinone] 1 alpha subco · P51970 · NDUFA8 on Sugi Atlas →

2,050 patent compounds predicted against NDUFA8, 1,220 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Auraptene Auraptene (SCHEMBL2535029) 1.00 5/20
Auraptene Auraptene (SCHEMBL2535034) 1.00 5/20
SCHEMBL8491443 SCHEMBL8491443 0.56 4/20
SCHEMBL8489900 SCHEMBL8489900 0.52 4/20
SCHEMBL8489907 SCHEMBL8489907 0.52 4/20
SCHEMBL8492838 SCHEMBL8492838 0.52 4/20
SCHEMBL8492845 SCHEMBL8492845 0.52 4/20
SCHEMBL8489902 SCHEMBL8489902 0.51 4/20
SCHEMBL8489908 SCHEMBL8489908 0.51 4/20
SCHEMBL8491154 SCHEMBL8491154 0.51 4/20
SCHEMBL8491160 SCHEMBL8491160 0.51 4/20
SCHEMBL8491619 SCHEMBL8491619 0.50 4/20
SCHEMBL8491624 SCHEMBL8491624 0.50 4/20
SCHEMBL8491634 SCHEMBL8491634 0.50 4/20
SCHEMBL8494171 SCHEMBL8494171 0.50 4/20
SCHEMBL8494175 SCHEMBL8494175 0.50 4/20
SCHEMBL8494177 SCHEMBL8494177 0.50 4/20
7-Prenyloxycoumarin 7-Prenyloxycoumarin (SCHEMBL4898255) 0.79 3/20
SCHEMBL712741 SCHEMBL712741 0.57 3/20
Geiparvarin Geiparvarin (SCHEMBL2532495) 0.56 3/20

Clinical trials — most relevant to NDUFA8 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease PHASE3COMPLETED
Effect of Montelukast Versus Co Enzyme in Sepsis PHASE2/PHASE3COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease PHASE2COMPLETED
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy PHASE2ACTIVE_NOT_RECRUITING
Parkinson's Disease Treatment With Coenzyme Q10 PHASE2COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
The Natural History of Mitochondrial Diseases nanRECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability. nanUNKNOWN
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Nicotinamide Riboside in Ulcerative Colitis nanRECRUITING
Natural History in Primary Mitochondrial Myopathies nanRECRUITING
Diagnostic Odyssey Survey 2 nanCOMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection nanCOMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy nanRECRUITING
Q10 Ubiquinol in Autism Spectrum Disorder and in Phelan-McDermid Syndrome. nanUNKNOWN
Survey on Supplement Use in Mitochondrial Disease nanCOMPLETED
Ccf mtDNA as a Neurodegenerative Biomarker nanUNKNOWN
Red Light Ptosis Proof-of-Concept nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a NDUFA8 binder may also engage these)

ProteinNameSimilarity
Q0MQB0 — 1.000 Q0MQB0 →
P0CB92 — 1.000 P0CB92 →
P0CB91 — 1.000 P0CB91 →
Q0MQB1 — 0.998 Q0MQB1 →
Q9DCJ5 — 0.996 Q9DCJ5 →
P42029 — 0.995 P42029 →
Q8LGE7 — 0.956 Q8LGE7 →
Q28CA1 — 0.956 Q28CA1 →
Q49B96 — 0.954 Q49B96 →
Q03015 — 0.954 Q03015 →
Q02379 — 0.953 Q02379 →
Q5RFJ0 — 0.952 Q5RFJ0 →
Q9SQT4 — 0.952 Q9SQT4 →
Q86WW8 — 0.951 Q86WW8 →
Q9SUD3 — 0.949 Q9SUD3 →
O43715 — 0.947 O43715 →
Q8K0C8 — 0.947 Q8K0C8 →
A1L3N6 — 0.947 A1L3N6 →
NDUFS5 NADH dehydrogenase [ubiquinone] iron-sulfur p 0.946 landscape →
Q0P451 — 0.946 Q0P451 →
Q9D8Z2 — 0.946 Q9D8Z2 →
Q9CPZ8 — 0.945 Q9CPZ8 →
Q7YRK6 — 0.945 Q7YRK6 →
Q8K199 — 0.945 Q8K199 →
Q945L0 — 0.945 Q945L0 →
P00429 — 0.944 P00429 →
Q2NKR3 — 0.944 Q2NKR3 →
Q3ZCK8 — 0.943 Q3ZCK8 →
Q53CG4 — 0.942 Q53CG4 →
P48504 — 0.942 P48504 →