ISG15 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4945778	0.46	1/20
SCHEMBL3070912	0.45	1/20
SCHEMBL4945586	0.45	1/20
SCHEMBL3130103	0.45	1/20
SCHEMBL15817526	0.45	1/20
SCHEMBL11563775	0.44	1/20
SCHEMBL13102294	0.44	1/20
SCHEMBL15818436	0.44	1/20
SCHEMBL4944811	0.43	1/20
SCHEMBL11121640	0.43	1/20
SCHEMBL5418249	0.41	1/20
SCHEMBL7293717	0.41	1/20
SCHEMBL11475097	0.41	1/20

Clinical trials — most relevant to ISG15 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Multi-site Adaptive Trials for COVID-19	PHASE3	COMPLETED
Efficacy of Adaptogens in Patients With Long COVID-19	PHASE2/PHASE3	COMPLETED
Plasma Exchange in Covid-19 Patients With Anti-interferon Autoantibodies	PHASE3	UNKNOWN
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)	PHASE3	UNKNOWN
Reducing Acute Severe Respiratory Events in Health Care Workers During the Covid-19 Pandemic With OM85	PHASE3	COMPLETED
Assessment of Efficacy of KAN-JANG® in Mild COVID-19	PHASE2/PHASE3	UNKNOWN
Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19	PHASE2	UNKNOWN
A Study Testing Emactinib Sulfate With Chemotherapy and Immunotherapy Before Surgery for Advanced Head and Neck Cancer	PHASE2	RECRUITING
Pembrolizumab + N-803 Alone or in Combination With PD-L1 t-haNK Cells for Resectable Head and Neck Squamous Cell Carcinoma	PHASE2	RECRUITING
A Phase I Study of Intravenous Recombinant Human IL-15 in Adults With Refractory Metastatic Malignant Melanoma and Metastatic Renal Cell Cancer	PHASE1	COMPLETED
Continuous Infusion of rhIL-15 for Adults With Advanced Cancer	PHASE1	COMPLETED
Study of Patients With Stage IV Malignant Melanoma Using PS-341 (Bortezomib, Velcade) and Interferon-alpha-2b in Malignant Melanoma	PHASE1	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Gene Expression Of Suppressor Of Cytokines in In Cutaneous Warts	nan	COMPLETED
Viral-Related Neutrophil Response and Condition Severity in People With ARDS	nan	COMPLETED
ADAR1 Expression Level in Rectal Cancer	nan	RECRUITING
PROSAIC-19 - Prospective Longitudinal Assessment in a COVID-19 Infected Cohort	nan	UNKNOWN
Immunological Profiling of Patients With COVID-19 in Respiratory Distress	nan	COMPLETED
Comparing Immune Activation and Latent HIV Reservoir Size Between People Living With HIV on Tenofovir-containing Versus NRTI-free ART	nan	ENROLLING_BY_INVITATION
Prediction of Abatacept Discontinuation Using Test Reflecting Immunological Remission in Rheumatoid Arthritis	nan	COMPLETED
Myeloid Cells in Patients With Covid-19 Pneumonia	nan	UNKNOWN
Pronostic Value of Type I ANTi-Interferon Antibodies in Patients With COVID-19 Acute Respiratory Failure	nan	COMPLETED
Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches	nan	UNKNOWN
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection	nan	UNKNOWN
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
Prediction of Response to Treatment of Patients With Chronic HCV Infection by Genetic Profile	nan	UNKNOWN
The Efficiency of Postoperative Interferon-alpha Treatment in p48 Positive Patients With Hepatocellular Carcinoma	nan	WITHDRAWN
Characterization of the IFN-I Response in Subjects Who Experienced Severe or Mild Forms of COVID-19	nan	RECRUITING
Recombinant Interferon Alfa-2b in Treating Patients With Melanoma	nan	COMPLETED
Nasal Immune Challenge Study	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ISG15 binder may also engage these)

Protein	Name	Similarity
O02741	—	0.997	O02741 →
Q64339	—	0.994	Q64339 →
P62865	—	0.985	P62865 →
P63072	—	0.984	P63072 →
Q05474	—	0.982	Q05474 →
Q60435	—	0.982	Q60435 →
P62868	—	0.982	P62868 →
JAK3	Tyrosine-protein kinase JAK3	0.981	landscape →
Q921A3	—	0.980	Q921A3 →
D3ZEY4	—	0.979	D3ZEY4 →
P0C2F1	—	0.978	P0C2F1 →
O15205	—	0.977	O15205 →
Q6P5E8	—	0.977	Q6P5E8 →
Q6MZZ7	—	0.976	Q6MZZ7 →
Q5R607	—	0.975	Q5R607 →
Q5BJS0	—	0.975	Q5BJS0 →
A4QND0	—	0.975	A4QND0 →
DHX30	ATP-dependent RNA helicase DHX30	0.975	landscape →
Q0JFN7	—	0.975	Q0JFN7 →
Q0D261	—	0.975	Q0D261 →
Q67UX0	—	0.975	Q67UX0 →
Q9NY93	—	0.974	Q9NY93 →
Q3TIU4	—	0.974	Q3TIU4 →
Q8WYJ6	—	0.974	Q8WYJ6 →
Q2KJG2	—	0.974	Q2KJG2 →
Q6K881	—	0.974	Q6K881 →
Q8VZI7	—	0.974	Q8VZI7 →
Q38SD2	—	0.974	Q38SD2 →
P40694	—	0.974	P40694 →
Q5BK10	—	0.974	Q5BK10 →