PDIA4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL7628574	0.33	3/20
SCHEMBL7637697	0.33	3/20
SCHEMBL3957917	0.62	2/20
SCHEMBL3961735	0.62	2/20
SCHEMBL4622327	0.42	2/20
SCHEMBL4622330	0.42	2/20
SCHEMBL4959831	0.42	2/20
SCHEMBL4959838	0.42	2/20
SCHEMBL2454844	0.41	2/20
SCHEMBL2454848	0.41	2/20
SCHEMBL1764410	0.41	2/20
SCHEMBL1764411	0.41	2/20
SCHEMBL7784472	0.35	2/20
SCHEMBL7633252	0.32	2/20
SCHEMBL7637705	0.32	2/20
SCHEMBL7784492	0.32	2/20
SCHEMBL7789896	0.32	2/20
SCHEMBL7789970	0.32	2/20
SCHEMBL7790428	0.32	2/20
Juglone (SCHEMBL34185)	1.00	1/20

Clinical trials — most relevant to PDIA4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes	PHASE4	UNKNOWN
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Evaluation of the Possible Safety and Efficacy of Dapagliflozin in the Prophylaxis of Doxorubicin-Induced Cardiotoxicity	PHASE2	RECRUITING
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy	PHASE2	COMPLETED
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma	PHASE2	RECRUITING
Decitabine and Venetoclax Treatment as Maintenance Therapy in Patients Post Allograft Stem Cell Transplant	PHASE1/PHASE2	RECRUITING
CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops	PHASE2	UNKNOWN
A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 Immunoglobulin G (rCD4-IgG) in HIV-1 Seropositive Women During the Last Trimester of Pregnancy and Their Newborns	PHASE1	COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors	PHASE1	COMPLETED
PBA Use for Treatment of ATF6-/- Patients	EARLY_PHASE1	SUSPENDED
Quantification of GADD34 Expression in RA	nan	COMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Effect of Protein on Endoplasmic Reticulum Stress	nan	NOT_YET_RECRUITING
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia	nan	RECRUITING
Genetic Studies of Lysosomal Storage Disorders	nan	ENROLLING_BY_INVITATION
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)	nan	RECRUITING
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)	nan	COMPLETED
Shwachman Diamond Syndrome Registry and Study	nan	RECRUITING
Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD)	nan	COMPLETED
Immunological Profile and Clinical Characteristics of Children Diagnosed With Chronic Granulomatous Disease	nan	UNKNOWN
Efficacy of Solarplast for Health and Oxidative Stress	nan	COMPLETED
Modes of Delivery Impact Maternal Oxidative Stress Biomarkers and Dynamic Thiol Disulphide Homeostasis	nan	COMPLETED
Transcranial Magnetic Stimulation (TMS) Studies of Dystonia	nan	COMPLETED
Endoplasmic Reticulum Stress and Resistance to Treatments in Ph-negative Myeloproliferative Neoplasms	nan	COMPLETED
Cellular Proteome From Leukocytes of Glaucoma Patients in Comparison With Patients With Parkinson's Disease	nan	WITHDRAWN
Cellular Proteome From Leukocytes of Glaucoma Patients in Comparison With Patients With Alzheimer's Disease	nan	WITHDRAWN
BAG3-DCM Natural History Study	nan	NOT_YET_RECRUITING
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a PDIA4 binder may also engage these)

Protein	Name	Similarity
P08003	—	1.000	P08003 →
Q29RV1	—	1.000	Q29RV1 →
P38659	—	1.000	P38659 →
P38657	—	0.999	P38657 →
Q53LQ0	—	0.998	Q53LQ0 →
Q4VIT4	—	0.997	Q4VIT4 →
P27773	—	0.996	P27773 →
P4HB	Protein disulfide-isomerase	0.996	landscape →
Q43116	—	0.996	Q43116 →
Q9XI01	—	0.995	Q9XI01 →
Q2HWU2	—	0.995	Q2HWU2 →
P34329	—	0.995	P34329 →
P29828	—	0.994	P29828 →
P11598	—	0.994	P11598 →
P09103	—	0.994	P09103 →
Q5R5B6	—	0.993	Q5R5B6 →
P04785	—	0.993	P04785 →
P05307	—	0.993	P05307 →
Q7XRB5	—	0.992	Q7XRB5 →
P80284	—	0.992	P80284 →
Q9FF55	—	0.992	Q9FF55 →
Q5RDG4	—	0.992	Q5RDG4 →
PDIA3	Protein disulfide-isomerase A3	0.992	landscape →
Q2KIL5	—	0.992	Q2KIL5 →
Q67IX6	—	0.992	Q67IX6 →
P09102	—	0.992	P09102 →
P52588	—	0.992	P52588 →
Q8JG64	—	0.991	Q8JG64 →
Q9XF61	—	0.991	Q9XF61 →
Q10057	—	0.991	Q10057 →