Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 4/20 | 0.60 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.60 |
| ▸ | PLA2G2A | P14555 | 9/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.45 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.45 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.45 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.45 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.45 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.45 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.45 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.45 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.45 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757197 | 0.92 | MTNR1B (0.52) | MTNR1BMTNR1APLA2G2AMAPTPLA2G1B | |
| SCHEMBL5697008 | 0.88 | MTNR1A (0.52) | MTNR1BMTNR1APLA2G2APLA2G1BPLA2G10 | |
| SCHEMBL13632216 | 0.88 | MTNR1A (0.54) | MTNR1BMTNR1APLA2G2AKDM4ENPC1 | |
| SCHEMBL26613 | 0.86 | PLA2G2A (0.59) | MTNR1BMTNR1APLA2G2AKDM4ENPC1 | |
| SCHEMBL14620974 | 0.86 | MTNR1B (0.52) | MTNR1BMTNR1APLA2G2AKDM4ENPC1 | |
| SCHEMBL2157014 | 0.86 | PLA2G2A (0.52) | MTNR1BMTNR1APLA2G2APLA2G1BPLA2G10 | |
| SCHEMBL8023979 | 0.85 | MTNR1A (0.46) | MTNR1BMTNR1APLA2G2AMAPTPLA2G1B | |
| SCHEMBL4789355 | 0.85 | PLA2G1B (0.46) | MTNR1BMTNR1APLA2G2AKDM4EPLA2G1B | |
| SCHEMBL26473 | 0.82 | MTNR1B (0.67) | MTNR1BMTNR1APLA2G2AMAPTCCR2 | |
| SCHEMBL2157125 | 0.82 | PLA2G2A (0.54) | MTNR1BMTNR1APLA2G2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1950200-B1 | [[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-11H-indol-4-yl]oxy]acetic acid methyl ester as sPLA2 inhibitor | LILLY CO ELI (US) | 2012-01-11 | — | — | EP | disclosed |
| EP-2341045-A1 | [[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-11H-indol-4-yl]oxy]acetic acid (acyloxy)alkyl or ((alkoxycarbonyl)oxy)alkyl ester as SPLA2 inhibitor | Eli Lilly and Company (US) | 2011-07-06 | — | — | EP | disclosed |
| EP-1950200-A1 | [[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-11H-indol-4-yl]oxy]acetic acid methyl ester as sPLA2 inhibitor | ELI LILLY AND COMPANY (US) | 2008-07-30 | — | — | EP | disclosed |
| EP-1202963-B1 | SPLA2 INHIBITORS | LILLY CO ELI (US) | 2007-01-03 | — | — | EP | disclosed |
| EP-1220839-B1 | HYDROXYFUNCTIONAL AMIDE 1H-INDOLE DERIVATIVES ACTIVE AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2006-12-06 | — | — | EP | disclosed |
| US-7026348-B2 | Indole sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2006-04-11 | — | — | US | disclosed |
| EP-1058547-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING THE PHOSPHOLIPASE INHIBITOR SODIUM 3-(2-AMINO-1,2-DIOXOETHYL)-2-ETHYL-1-PHENYLMETHYL)-1H-INDOL-4-YL]OXY]ACETATE | SHIONOGI & CO (JP) | 2005-11-23 | — | — | EP | disclosed |
| US-6939890-B2 | Antiinflammatory agents; sepsis shock; rheumatic disorders | ELI LILLY AND COMPANY (US) | 2005-09-06 | — | — | US | disclosed |
| US-6831095-B1 | Treatment of rheumatoid arthritis | ELI LILLY AND COMPANY | 2004-12-14 | — | — | US | disclosed |
| US-6706752-B1 | HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2 INHIBITORS FOR INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF INFLAMMATORY DISEASES SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-16 | — | — | US | disclosed |
| US-5919810-A | SEPTIC SHOCK | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5919943-A | INHIBITION OF SPLA2 | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| WO-1999024026-A2 | METHOD FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH APOPTOSIS USING N-HETEROCYCLIC GLYOXYLAMIDE COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 1999-05-20 | — | — | WO | disclosed |
| WO-1999024033-A1 | METHOD FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH APOPTOSIS USING N-HETEROCYCLIC GLYOXYLAMIDE COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 1999-05-20 | — | — | WO | disclosed |
| EP-0887342-A2 | Process for preparing 4-substituted-1H-indole-3-glyoxamides | ELI LILLY AND COMPANY (US) | 1998-12-30 | — | — | EP | disclosed |
| WO-1998047507-A1 | METHOD FOR THE TREATMENT OF STROKE USING N-HETEROCYCLIC GLYOXYLAMIDE COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 1998-10-29 | — | — | WO | disclosed |
| WO-1998047508-A1 | METHOD FOR THE TREATMENT OF STROKE USING N-HETEROCYCLIC GLYOXYLAMIDE COMPOUNDS | SHIONOGI & CO., LTD. (JP) | 1998-10-29 | — | — | WO | disclosed |
| US-5733923-A | SECRETORY PANCREATIC PHOSPHOLIPASE A2 | ELI LILLY AND COMPANY (US) | 1998-03-31 | — | — | US | disclosed |
| US-5654326-A | SEPTIC SHOCK; HUMAN NONPANCREATIC SECRETORY PHOSPHOLIPASE | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0675110-A1 | 1H-Indole-3-glyoxylamide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1995-10-04 | — | — | EP | disclosed |