PRPF3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Molibresib (SCHEMBL1872390)	1.00	1/20
Molibresib (SCHEMBL12671490)	1.00	1/20
Molibresib (SCHEMBL12966358)	1.00	1/20
SCHEMBL9998851	0.91	1/20
SCHEMBL14756282	0.88	1/20
SCHEMBL15980874	0.88	1/20
SCHEMBL12966165	0.87	1/20
SCHEMBL14756215	0.87	1/20
SCHEMBL14756339	0.87	1/20
SCHEMBL15980861	0.87	1/20
SCHEMBL9998825	0.86	1/20
SCHEMBL15980893	0.86	1/20
SCHEMBL15980803	0.86	1/20
SCHEMBL1874116	0.85	1/20
SCHEMBL12671221	0.85	1/20
SCHEMBL14756021	0.85	1/20
SCHEMBL14756240	0.85	1/20
SCHEMBL14756287	0.85	1/20
SCHEMBL14756335	0.85	1/20
SCHEMBL14756409	0.85	1/20

Clinical trials — most relevant to PRPF3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Personalized Antisense Oligonucleotide Therapy for a Single Participant With PRPH2 Mutation Associated With Retinal Dystrophy	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
SAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects	PHASE1	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Natural History of PRPF31 Mutation-Associated Retinal Dystrophy	nan	ACTIVE_NOT_RECRUITING
Clinical and Genetic Findings in Patients With PRPF31-associated Retinitis Pigmentosa	nan	COMPLETED
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
Genetic Investigation of Cancer Predisposition	nan	NOT_YET_RECRUITING
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population	nan	COMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study)	nan	RECRUITING
Mutations and Phenotypes of Unclassifiable Inherited Bone Marrow Failure Syndromes	nan	RECRUITING
Efficacy and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated Cystic Fibrosis (CF)	nan	COMPLETED
Relapsed and Progressive Sonic Hedgehog Medulloblastoma With U1 Mutation Registry Study	nan	RECRUITING
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis	nan	COMPLETED
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS	nan	RECRUITING
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC	nan	UNKNOWN
Longitudinal Study of Neurogenetic Disorders	nan	RECRUITING
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
NFC Changes in SLE Patients and Its Correlation With Anti-U1RNPAntibodies and Disease Activity	nan	UNKNOWN
SMN Circular RNAs as Potential Biomarkers for the Therapeutic Response to Nusinersen in Spinal Muscular Atrophy Patients	nan	UNKNOWN
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing	nan	RECRUITING
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study	nan	ACTIVE_NOT_RECRUITING
Molecular Genetics of Retinal Degenerations	nan	COMPLETED
Identification of New FTLD Genes	nan	UNKNOWN
Study of Constitutional Platelet Disease	nan	UNKNOWN
MicroRNA-1 (miRNA-1) and MicroRNA-133a (miRNA-133a) Levels After Acute Exercise in Ultimate Frisbee Athletes	nan	UNKNOWN
Nerve Ultrasound in Acquired and Genetic Sensory Neuronopathies	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a PRPF3 binder may also engage these)

Protein	Name	Similarity
Q922U1	—	1.000	Q922U1 →
Q5ZJ85	—	1.000	Q5ZJ85 →
Q5R5F1	—	1.000	Q5R5F1 →
Q2KIA6	—	1.000	Q2KIA6 →
SF3A1	Splicing factor 3A subunit 1	0.982	landscape →
P29540	—	0.981	P29540 →
EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.981	landscape →
A2VDN6	—	0.981	A2VDN6 →
Q1RMM1	—	0.981	Q1RMM1 →
Q6U6G5	—	0.980	Q6U6G5 →
Q40554	—	0.980	Q40554 →
Q8WU90	—	0.979	Q8WU90 →
P23116	—	0.978	P23116 →
Q1JU68	—	0.978	Q1JU68 →
Q2HJ41	—	0.978	Q2HJ41 →
Q6PCR7	—	0.978	Q6PCR7 →
Q5RAD5	—	0.978	Q5RAD5 →
Q8K4Z5	—	0.977	Q8K4Z5 →
O75391	—	0.977	O75391 →
A2VD00	—	0.977	A2VD00 →
Q5NVI3	—	0.976	Q5NVI3 →
Q9Z1M8	—	0.976	Q9Z1M8 →
O75937	—	0.976	O75937 →
Q3TIV5	—	0.976	Q3TIV5 →
Q7SYJ9	—	0.976	Q7SYJ9 →
SAP30BP	SAP30-binding protein	0.975	landscape →
Q9JKB8	—	0.975	Q9JKB8 →
A4II09	—	0.975	A4II09 →
Q7TNE3	—	0.974	Q7TNE3 →
Q8BM39	—	0.974	Q8BM39 →