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Sugi Predict / Targets / PRPF40A

PRPF40A

Pre-mRNA-processing factor 40 homolog A · O75400 · PRPF40A on Sugi Atlas →

1,891 patent compounds predicted against PRPF40A, 1,674 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Molibresib Molibresib (SCHEMBL1872390) 1.00 1/20
Molibresib Molibresib (SCHEMBL12671490) 1.00 1/20
Molibresib Molibresib (SCHEMBL12966358) 1.00 1/20
SCHEMBL9998851 SCHEMBL9998851 0.91 1/20
SCHEMBL14756282 SCHEMBL14756282 0.88 1/20
SCHEMBL15980874 SCHEMBL15980874 0.88 1/20
SCHEMBL12966165 SCHEMBL12966165 0.87 1/20
SCHEMBL14756215 SCHEMBL14756215 0.87 1/20
SCHEMBL14756339 SCHEMBL14756339 0.87 1/20
SCHEMBL15980861 SCHEMBL15980861 0.87 1/20
SCHEMBL9998825 SCHEMBL9998825 0.86 1/20
SCHEMBL15980893 SCHEMBL15980893 0.86 1/20
SCHEMBL15980803 SCHEMBL15980803 0.86 1/20
SCHEMBL1874116 SCHEMBL1874116 0.85 1/20
SCHEMBL12671221 SCHEMBL12671221 0.85 1/20
SCHEMBL14756021 SCHEMBL14756021 0.85 1/20
SCHEMBL14756240 SCHEMBL14756240 0.85 1/20
SCHEMBL14756287 SCHEMBL14756287 0.85 1/20
SCHEMBL14756335 SCHEMBL14756335 0.85 1/20
SCHEMBL14756409 SCHEMBL14756409 0.85 1/20

Clinical trials — most relevant to PRPF40A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision PHASE3COMPLETED
Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients PHASE1/PHASE2COMPLETED
MAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects (Wallaby) PHASE1COMPLETED
SAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects PHASE1COMPLETED
Clinical and Genetic Findings in Patients With PRPF31-associated Retinitis Pigmentosa nanCOMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study) nanRECRUITING
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic nanCOMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
Identification of New FTLD Genes nanUNKNOWN
Natural History of PRPF31 Mutation-Associated Retinal Dystrophy nanACTIVE_NOT_RECRUITING
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact nanUNKNOWN
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Cancer in Inherited Bone Marrow Failure Syndromes nanRECRUITING
Omeprazole and Famotidine in Chronic Dysfunction of the Transplanted Kidney nanUNKNOWN
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia nanRECRUITING
Genetic Investigation of Cancer Predisposition nanNOT_YET_RECRUITING
Exome Analysis in Hearing Impaired Patients nanUNKNOWN
Study of Constitutional Platelet Disease nanUNKNOWN
Biocollection in MyeloDysplastic Syndrome (P-MDS) nanRECRUITING
Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks nanRECRUITING
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Mutations and Phenotypes of Unclassifiable Inherited Bone Marrow Failure Syndromes nanRECRUITING
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population nanCOMPLETED
Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis nanUNKNOWN
Identification of the Genetic Causes of Rare Diseases With Negative Exome Findings nanUNKNOWN
Next Generation Sequencing of Normal Tissues Prospectively in Pediatric Oncology Patients nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a PRPF40A binder may also engage these)

ProteinNameSimilarity
Q9R1C7 — 1.000 Q9R1C7 →
P34600 — 0.983 P34600 →
B6EUA9 — 0.982 B6EUA9 →
Q6NWY9 — 0.980 Q6NWY9 →
Q6NZN0 — 0.979 Q6NZN0 →
RBM26 RNA-binding protein 26 0.979 landscape →
P51115 — 0.979 P51115 →
Q8CGF7 — 0.978 Q8CGF7 →
Q3UQU0 — 0.978 Q3UQU0 →
E1BTG2 — 0.978 E1BTG2 →
Q8QG78 — 0.978 Q8QG78 →
Q61584 — 0.978 Q61584 →
Q5XI81 — 0.978 Q5XI81 →
D3ZTQ1 — 0.978 D3ZTQ1 →
Q5BJ56 — 0.977 Q5BJ56 →
Q4KKX4 — 0.977 Q4KKX4 →
CDK11A Cyclin-dependent kinase 11A 0.977 landscape →
BRD2 Bromodomain-containing protein 2 0.977 landscape →
Q2T9I5 — 0.977 Q2T9I5 →
Q80W14 — 0.977 Q80W14 →
SMARCC2 SWI/SNF complex subunit SMARCC2 0.977 landscape →
Q7ZTQ5 — 0.976 Q7ZTQ5 →
Q9WVR4 — 0.976 Q9WVR4 →
P24788 — 0.976 P24788 →
TCERG1 Transcription elongation regulator 1 0.976 landscape →
Q6DDU9 — 0.976 Q6DDU9 →
Q4VGL6 — 0.976 Q4VGL6 →
Q99KG3 — 0.976 Q99KG3 →
Q86XZ4 — 0.976 Q86XZ4 →
FXR1 RNA-binding protein FXR1 0.976 landscape →