Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.74 |
| ▸ | RGS12 | O14924 | 1/20 | 0.74 |
| ▸ | PMM2 | O15305 | 1/20 | 0.74 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.74 |
| ▸ | GMNN | O75496 | 1/20 | 0.74 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | CYBB | P04839 | 1/20 | 0.74 |
| ▸ | BCHE | P06276 | 1/20 | 0.74 |
| ▸ | GLA | P06280 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL193047 | 0.86 | METAP2 (0.79) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| Ebselen SCHEMBL4406056 | 0.85 | METAP2 (1.00) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| Ebselen SCHEMBL33829 | 0.85 | METAP2 (1.00) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| Ebselen SCHEMBL29370082 | 0.85 | METAP2 (1.00) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| SCHEMBL28783439 | 0.84 | METAP2 (0.77) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| Ebselen SCHEMBL19064566 | 0.84 | METAP2 (0.96) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| Ebselen SCHEMBL20678555 | 0.84 | METAP2 (0.96) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| Ebselen SCHEMBL20477111 | 0.84 | METAP2 (0.96) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| SCHEMBL10501773 | 0.83 | METAP2 (0.70) | METAP2HDAC6KDM4EMEN1QSOX1 | |
| SCHEMBL10501092 | 0.83 | METAP2 (1.00) | METAP2HDAC6KDM4EMEN1QSOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112110877-B | Benzisoselenazolone derivative, preparation method and application thereof in anti-coronavirus medicament | 青岛大学 | 2023-09-08 | — | — | CN | disclosed |
| US-11013730-B1 | Composition comprising selenazol or thiazalone derivatives and silver and method of treatment therewith | THIOREDOXIN SYSTEMS AB (SE) | 2021-05-25 | — | — | US | disclosed |
| US-10058542-B1 | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith | THIOREDOXIN SYSTEMS AB (SE) | 2018-08-28 | — | — | US | disclosed |
| US-20140088149-A1 | BACTERIAL THIOREDOXIN REDUCTASE INHIBITORS AND METHODS FOR USE THEREOF | THIOREDOXIN SYSTEM AB. (SE) | 2014-03-27 | — | — | US | disclosed |
| US-8592468-B2 | Bacterial thioredoxin reductase inhibitors and methods for use thereof | THIOREDOXIN SYSTEMS AB (SE) | 2013-11-26 | — | — | US | disclosed |
| US-8426452-B2 | Process for the treatment and prevention of diseases caused by fungi | BILLACK BLASE CHRISTOPHER (US) | 2013-04-23 | — | — | US | disclosed |
| US-20110288130-A1 | BACTERIAL THIOREDOXIN REDUCTASE INHIBITORS AND METHODS FOR USE THEREOF | THIOREDOXIN SYSTEMS AB (SE) | 2011-11-24 | — | — | US | disclosed |
| US-20090239913-A1 | Process for the treatment and prevention of diseases caused by fungi | BILLACK BLASE CHRISTOPHER | 2009-09-24 | — | — | US | disclosed |
| US-20090005422-A1 | BACTERIAL THIOREDOXIN REDUCTASE INHIBITORS AND METHODS FOR USE THEREOF | THIOREDOXIN SYSTEMS AB (SE) | 2009-01-01 | — | — | US | disclosed |
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| EP-0165534-B1 | S-(CARBAMOYL-PHENYLSELENYL) DERIVATIVES OF GLUTATHION AND OF AMINO MERCAPTOCARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1989-03-15 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0198277-A1 | Diseleno-bis-benzamides of primary and secondary amines, processes for their production and pharmaceutical preparations containing them | A. Nattermann & Cie. GmbH (DE) | 1986-10-22 | — | — | EP | disclosed |
| US-4618669-A | FOR CELL INJURIES CAUSED BY ACTIVE OXYGEN METABOLITES | A. NATTERMANN & CIE GMBH (DE) | 1986-10-21 | — | — | US | disclosed |
| EP-0165534-A2 | S-(carbamoyl-phenylselenyl) derivatives of glutathion and of amino mercaptocarboxylic acids, process for their preparation and pharmaceutical preparations containing them | A. Nattermann & Cie. GmbH (DE) | 1985-12-27 | — | — | EP | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |
| US-4418069-A | Benzisoselenazolones and process for the treatment of rheumatic and arthritic diseases using them | A. NATTERMANN & CIE GMBH (DE) | 1983-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005422-A1 | BACTERIAL THIOREDOXIN REDUCTASE INHIBITORS AND METHODS FOR USE THEREOF | GSR, PRDX3, TXNRD3 | METAP2 1795/4885HDAC6 1090/4885KDM4E 3142/4885 |
| US-20140088149-A1 | BACTERIAL THIOREDOXIN REDUCTASE INHIBITORS AND METHODS FOR USE THEREOF | GSR, PRDX3, TXNRD3 | METAP2 1795/4885HDAC6 1090/4885KDM4E 3142/4885 |
| US-11013730-B1 | Composition comprising selenazol or thiazalone derivatives and silver and method of treatment therewith | SELENOI, TST, SCLY | METAP2 1704/4885HDAC6 823/4885KDM4E 4710/4885 |
| US-20110288130-A1 | BACTERIAL THIOREDOXIN REDUCTASE INHIBITORS AND METHODS FOR USE THEREOF | GSR, PRDX3, TXNRD3 | METAP2 1795/4885HDAC6 1090/4885KDM4E 3142/4885 |
| US-20090239913-A1 | Process for the treatment and prevention of diseases caused by fungi | ABCB11, ATP1A1, MAN2B1 | METAP2 1338/4885HDAC6 1587/4885KDM4E 3988/4885 |
| US-10058542-B1 | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith | SELENOI, TST, GSS | METAP2 2771/4885HDAC6 1247/4885KDM4E 4515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.