RGS8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13517154	1.00	20/20
SCHEMBL13517607	1.00	20/20
SCHEMBL13516928	1.00	19/20
SCHEMBL13516931	1.00	19/20
SCHEMBL13516952	1.00	19/20
SCHEMBL13517061	1.00	19/20
SCHEMBL13517256	1.00	19/20
SCHEMBL13517312	1.00	19/20
SCHEMBL13517514	1.00	19/20
SCHEMBL13517646	1.00	19/20
SCHEMBL13517789	1.00	19/20
SCHEMBL13517490	0.89	19/20
SCHEMBL13517266	0.88	19/20
SCHEMBL13517231	0.86	19/20
SCHEMBL13517242	0.84	19/20
SCHEMBL13517756	0.84	19/20
SCHEMBL13516956	0.82	19/20
SCHEMBL13517241	0.81	19/20
SCHEMBL13517152	0.79	19/20
SCHEMBL13517044	0.79	19/20

Clinical trials — most relevant to RGS8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
Phase 2A Study of GM 608 in Mild to Moderate Parkinson Disease	PHASE2	COMPLETED
Role of TLR4 in Environmental Asthma	PHASE1	COMPLETED
GSNOR Phenotyping/GSNO Challenge in Severe Asthma	EARLY_PHASE1	COMPLETED
Relationship Between Genes Important in Blood Pressure Regulation and Blood Pressure Therapy in Hypertension	nan	COMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
Neuropsychopathological Study of Autism	nan	UNKNOWN
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Inherited Reproductive Disorders	nan	RECRUITING
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage	nan	ENROLLING_BY_INVITATION
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity	nan	NOT_YET_RECRUITING
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation	nan	UNKNOWN
Genetic Study in Patients With Stage II or Stage III Colon Cancer	nan	COMPLETED
Brain Tissue Integrity and Autonomic Function Alterations in Childhood OSA and ADHD, and After Adenotonsillectomy.	nan	UNKNOWN
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Insulin Detemir in Obesity Management	nan	ACTIVE_NOT_RECRUITING
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Pathophysiology of Diabetic Gastroparesis	nan	UNKNOWN
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)	nan	COMPLETED
Identification of an Asthma Susceptibility Gene on 3P	nan	COMPLETED
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms	nan	COMPLETED
Genetic Contribution of Pain and Inflammation in IBS	nan	COMPLETED
Pharmacogenetics and Cardiovascular Events	nan	COMPLETED
Imaging and Genetic Investigation of Learning and Decision Making	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a RGS8 binder may also engage these)

Protein	Name	Similarity
P49804	—	1.000	P49804 →
Q8BXT1	—	1.000	Q8BXT1 →
Q95K68	—	0.997	Q95K68 →
Q7SZC6	—	0.997	Q7SZC6 →
P56700	—	0.995	P56700 →
RGS16	Regulator of G-protein signaling 16	0.995	landscape →
Q4R525	—	0.994	Q4R525 →
RGS4	Regulator of G-protein signaling 4	0.993	landscape →
Q0R4E4	—	0.992	Q0R4E4 →
P49799	—	0.992	P49799 →
Q29RM9	—	0.992	Q29RM9 →
O46471	—	0.991	O46471 →
Q0P5H5	—	0.990	Q0P5H5 →
O08899	—	0.989	O08899 →
P97428	—	0.989	P97428 →
Q3S853	—	0.988	Q3S853 →
O15539	—	0.988	O15539 →
Q5R747	—	0.988	Q5R747 →
F1S668	—	0.987	F1S668 →
O08850	—	0.986	O08850 →
Q6DGI0	—	0.985	Q6DGI0 →
Q9JHX0	—	0.985	Q9JHX0 →
P49800	—	0.985	P49800 →
Q864Z2	—	0.985	Q864Z2 →
Q3T0T8	—	0.983	Q3T0T8 →
P41220	—	0.982	P41220 →
O94810	—	0.978	O94810 →
Q6RG78	—	0.978	Q6RG78 →
O08849	—	0.978	O08849 →
P97844	—	0.977	P97844 →