SCP2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL14267417	1.00	1/20
SCHEMBL7812704	0.93	1/20
SCHEMBL3501312	0.82	1/20
SCHEMBL7815701	0.79	1/20
SCHEMBL7812016	0.78	1/20
SCHEMBL62370	0.77	1/20
SCHEMBL4662862	0.77	1/20
SCHEMBL19646592	0.77	1/20
SCHEMBL26434823	0.76	1/20
SCHEMBL13201656	0.76	1/20
SCHEMBL26434988	0.75	1/20
SCHEMBL61656	0.75	1/20
SCHEMBL16812947	0.74	1/20
SCHEMBL60937	0.72	1/20
SCHEMBL13182638	0.72	1/20
SCHEMBL4664473	0.72	1/20
SCHEMBL13881978	0.72	1/20
SCHEMBL25188913	0.71	1/20
SCHEMBL14267416	0.71	1/20
SCHEMBL61937	0.69	1/20

Clinical trials — most relevant to SCP2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons	PHASE4	COMPLETED
The Low HDL On Six Weeks Statin Therapy (LOW) Study	PHASE4	UNKNOWN
Effects of Pioglitazone on High-density Lipoprotein (HDL) Function in Persons With Diabetes	PHASE3	COMPLETED
Smith-Lemli-Opitz Syndrome and Cholic Acid	PHASE1/PHASE2	COMPLETED
Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients with Non-alcoholic Steatohepatitis	PHASE2	ACTIVE_NOT_RECRUITING
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis	PHASE2	UNKNOWN
Hereditary Sensory Neuropathy Serine Trial	PHASE2	UNKNOWN
Epidemiology of Atherosclerosis	nan	COMPLETED
Exome Sequencing in Autistic Spectrum Disorder	nan	COMPLETED
The Genetic, Protein, and Lipid Basis of Variation in Cholesterol Efflux	nan	COMPLETED
Statin Therapy and COVID-19 Infection	nan	COMPLETED
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL)	nan	COMPLETED
Study of Changes in Total Cholesterol Levels as a Function of Consuming a Supplement Designed to Improve Cardiovascular Health	nan	UNKNOWN
The Roles of SAH Gene Family in Athrogenic Dyslipidemia in Postmenopausal Women	nan	UNKNOWN
Association of SGLT2 Inhibitors Therapy With Elastographic and Molecular Markers of Liver Injury in Type 2 Diabetes	nan	COMPLETED
Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population	nan	RECRUITING
Epigenomic and Metabolomic Signatures of APOA2 Gene by Saturated Fat Interaction	nan	COMPLETED
Effect of Laparoscopic Splenectomy on Lipid Profiles in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)	nan	NOT_YET_RECRUITING
Gene Expression in Obesity and Insulin Resistance	nan	COMPLETED
HIV Reverse Cholesterol Transport Study	nan	UNKNOWN
Effect of LSD on Lipid Profiles in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)	nan	NOT_YET_RECRUITING
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
Developing and Implementing Familial Hypercholesterolemia Registry	nan	UNKNOWN
Genetic Epidemiology of Hypertriglyceridemia	nan	COMPLETED
Nutrigenetic Intervention on Blood Lipid Markers and Body Composition of Adults With Overweight and Obesity	nan	COMPLETED
Mechanisms of Glucose Lowering Effect of Colesevelam HCl	nan	COMPLETED
Effects of Colesevelam HCl On Bile Acid Kinetics	nan	COMPLETED
Polycystic Ovary Syndrome in Type 1 Diabetes	nan	NOT_YET_RECRUITING
Genetic Origin of Lipid Disorders	nan	UNKNOWN
Genetic and Metabolism of Post-prandial HDL Particles	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SCP2 binder may also engage these)

Protein	Name	Similarity
O62742	—	1.000	O62742 →
P32020	—	1.000	P32020 →
P11915	—	1.000	P11915 →
P07857	—	1.000	P07857 →
Q07598	—	1.000	Q07598 →
Q60587	—	0.990	Q60587 →
Q99JY0	—	0.990	Q99JY0 →
P27796	—	0.990	P27796 →
Q5R1W7	—	0.989	Q5R1W7 →
G5EDP2	—	0.989	G5EDP2 →
A0AAD6ITA8	—	0.987	A0AAD6ITA8 →
P34255	—	0.987	P34255 →
O46629	—	0.987	O46629 →
HADHB	Trifunctional enzyme subunit beta, mitochondrial	0.986	landscape →
A0AAD6NF83	—	0.986	A0AAD6NF83 →
Q05493	—	0.986	Q05493 →
A0AAD6NLP7	—	0.985	A0AAD6NLP7 →
P21775	—	0.985	P21775 →
Q8HXX4	—	0.985	Q8HXX4 →
Q570C8	—	0.984	Q570C8 →
Q8LF48	—	0.983	Q8LF48 →
Q921H8	—	0.983	Q921H8 →
P33291	—	0.983	P33291 →
Q56WD9	—	0.982	Q56WD9 →
Q39VG1	—	0.981	Q39VG1 →
P33290	—	0.981	P33290 →
C8YNG6	—	0.981	C8YNG6 →
Q5RES5	—	0.981	Q5RES5 →
O49809	—	0.981	O49809 →
Q3T0R7	—	0.981	Q3T0R7 →