Clobuzarit

Clobuzarit

SCHEMBL187456

CC(C)(OCc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)O

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SLC16A3 O15427 10/20 0.62
SLC16A1 P53985 6/20 0.62
MCTS1 Q9ULC4 5/20 0.62
PPARA Q07869 6/20 0.52
MEN1 O00255 2/20 0.51
MAPT P10636 2/20 0.51
KMT2A Q03164 2/20 0.51
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C19 P33261 1/20 0.51
PPARG P37231 3/20 0.50
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
PKM P14618 1/20 0.46
FABP2 P12104 1/20 0.45
SLC22A12 Q96S37 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2221138 0.87 SLC16A3 (0.53) SLC16A3SLC16A1MCTS1PPARG
SCHEMBL11653742 0.82 PPARA (0.49) SLC16A3SLC16A1MCTS1PPARAMEN1
SCHEMBL10840399 0.81 MAOA (0.49) SLC16A3SLC16A1MCTS1PPARAMEN1
SCHEMBL11228891 0.81 MEN1 (0.47) SLC16A3SLC16A1MCTS1PPARAMEN1
Clobuzarit SCHEMBL8700294 0.80 ACE (0.53) SLC16A3SLC16A1MCTS1PPARAPPARG
SCHEMBL883026 0.79 SLC16A3 (0.55) SLC16A3SLC16A1MCTS1PPARAKMT2A
SCHEMBL11657373 0.78 PPARA (0.48) SLC16A3SLC16A1MCTS1PPARAMEN1
SCHEMBL2215266 0.78 RXRA (0.46) SLC16A3SLC16A1MCTS1PPARAMAPT
SCHEMBL2352150 0.78 RXRA (0.46) SLC16A3SLC16A1MCTS1PPARACYP3A4
SCHEMBL8935661 0.78 SLC16A3 (0.46) SLC16A3SLC16A1MCTS1PPARAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 619 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3752201-B1 SUSPENSION OF NANOSCALE, ORGANIC PARTICLES AND PROCESS FOR PRODUCTION THEREOF UNIV FRIEDRICH ALEXANDER ER (DE) 2023-11-22 EP claimed
EP-3752201-A1 SUSPENSION OF NANOSCALE, ORGANIC PARTICLES AND PROCESS FOR PRODUCTION THEREOF Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) 2020-12-23 EP claimed
WO-2019158509-A1 SUSPENSION OF NANOSCALE, ORGANIC PARTICLES AND PROCESS FOR PRODUCTION THEREOF Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) 2019-08-22 WO claimed
US-20150328323-A1 Nitric Oxide Releasing Produgs of Therapeutic Agents SATYAM APPARAO (IN) 2015-11-19 US claimed
US-9161927-B2 Drug combinations containing PDE4 inhibitors and NSAIDs BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2015-10-20 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
WO-2014111957-A1 NITRIC OXIDE RELEASING PRODRUGS OF THERAPEUTIC AGENTS SATYAM APPARAO (IN) 2014-07-24 WO claimed
US-8759326-B2 Drug combinations containing PDE4 inhibitors and NSAIDs BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-06-24 US claimed
EP-1200110-B1 IN VIVO INDUCTION FOR ENHANCED FUNCTION OF ISOLATED HEPATOCYTES ORGANOGENESIS INC (US) 2014-04-23 EP claimed
US-20140031343-A1 DRUG COMBINATIONS CONTAINING PDE4 INHIBITORS AND NSAIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-01-30 US claimed
WO-2003024489-A2 COMBINATION OF A NSAID AND A PDE-4 INHIBITOR ALTANA PHARMA AG (DE) 2003-03-27 WO claimed
US-20020085995-A1 In vivo induction for enhanced function of isolated hepatocytes SILICON VALLEY BANK 2002-07-04 US claimed
US-6394812-B1 LIVER CELL CULTURE ORGANOGENESIS INC. 2002-05-28 US claimed
EP-1200110-A1 IN VIVO INDUCTION FOR ENHANCED FUNCTION OF ISOLATED HEPATOCYTES ORGANOGENESIS INC. (US) 2002-05-02 EP claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2001007069-A1 IN VIVO INDUCTION FOR ENHANCED FUNCTION OF ISOLATED HEPATOCYTES ORGANOGENESIS INC. (US) 2001-02-01 WO claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
WO-1998022114-A1 A METHOD FOR PROMOTING TISSUE REPAIR DUMEX-ALPHARMA A/S (DK) 1998-05-28 WO claimed
EP-0037697-B1 DIOXOLANE DERIVATIVES FOR USE AS CHEMICAL INTERMEDIATES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-08-01 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140031343-A1 DRUG COMBINATIONS CONTAINING PDE4 INHIBITORS AND NSAIDS PTGER4, PDE4A, PDE12 SLC16A3 3332/4885SLC16A1 4014/4885MCTS1 3799/4885
US-20150328323-A1 Nitric Oxide Releasing Produgs of Therapeutic Agents NOS2, NOS1, PTGIS SLC16A3 1611/4885SLC16A1 1356/4885MCTS1 4638/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.