SLC22A4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2215409	1.00	1/20
SCHEMBL9985141	1.00	1/20
SCHEMBL9986385	1.00	1/20
SCHEMBL175156	0.76	1/20
SCHEMBL745229	0.76	1/20
SCHEMBL12039657	0.76	1/20
SCHEMBL20925250	0.72	1/20
SCHEMBL20925187	0.70	1/20
SCHEMBL2217967	0.69	1/20
SCHEMBL13881702	0.67	1/20
SCHEMBL28099455	0.64	1/20
SCHEMBL9604219	0.55	1/20
SCHEMBL9604220	0.55	1/20
SCHEMBL1331027	0.55	1/20
SCHEMBL26315497	0.55	1/20
SCHEMBL14330476	0.54	1/20
SCHEMBL188140	0.52	1/20
SCHEMBL2218757	0.52	1/20
SCHEMBL2954946	0.52	1/20
SCHEMBL29418359	0.52	1/20

Clinical trials — most relevant to SLC22A4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Genetic Basis for Variation in the Renal Elimination of Metformin	PHASE4	COMPLETED
Effect of Age on the Renal Clearance of Adefovir	PHASE4	WITHDRAWN
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation	PHASE2/PHASE3	UNKNOWN
BSEP Function Rescue During Childhood Inhereditary Cholestatic Diseases	PHASE2/PHASE3	WITHDRAWN
CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops	PHASE2	UNKNOWN
Effect of, OAT3, on the Renal Secretion of Cefotaxime	PHASE1	COMPLETED
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer	EARLY_PHASE1	UNKNOWN
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters	EARLY_PHASE1	COMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
SLC13A5 Deficiency Natural History Study - Remote Only	nan	ENROLLING_BY_INVITATION
Influence of OCTN2 Variants on Carnitine Status and Plasma Triglycerides	nan	COMPLETED
Cancer and Hearing Loss Related in Children	nan	COMPLETED
Study of ABCB1,SLC22A16 Drug Transporter Genes and Doxorubicin and Cyclophosphamide Toxicity in Brest Cancer Patient	nan	UNKNOWN
Gastrostomy-Biliary Diversion: Innovative Management for Bile Canalicular Transport Disorders	nan	UNKNOWN
Bile Acid Effects in Fetal Arrhythmia Study	nan	UNKNOWN
Autonomic Function in Patients With COPD	nan	COMPLETED
Gyrate Atrophy Ocular and Systemic Study	nan	ACTIVE_NOT_RECRUITING
Oxalate and Citrate in Humans - Response to Citrate	nan	RECRUITING
SLC13A5 Deficiency Natural History Study - United States Only	nan	ENROLLING_BY_INVITATION
Expression of SLC25A48 in Chronic Obstructive Pulmonary Disease	nan	NOT_YET_RECRUITING
Clinical Phenotypic Characteristics of SC26A4	nan	UNKNOWN
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs	nan	COMPLETED
Genotype-phenotype Correlation of SLC26A4 in CI Patients With EVA	nan	UNKNOWN
Understanding Methotrexate Induced Gastrointestinal Intolerance in Juvenile Idiopathic Arthritis and Childhood Leukemia	nan	COMPLETED
ADPKD Alterations in Hepatic Transporter Function	nan	COMPLETED
Impact of Genetics on Metformin Pharmacokinetics	nan	COMPLETED
Choroid Plexus Dysfunction in Neurological Diseases	nan	RECRUITING
Genetic and Biohumoral Factors Involved in Menière's Disease and Their Correlation With Phenotypes	nan	RECRUITING
Renal and Hepatic Clearance Following High-Dose Methotrexate in Childhood ALL	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC22A4 binder may also engage these)

Protein	Name	Similarity
A9CB25	—	1.000	A9CB25 →
O76082	—	1.000	O76082 →
Q9R141	—	0.999	Q9R141 →
Q9Z306	—	0.997	Q9Z306 →
Q9Z0E8	—	0.996	Q9Z0E8 →
O70594	—	0.995	O70594 →
Q9R0W2	—	0.993	Q9R0W2 →
Q8MJI6	—	0.990	Q8MJI6 →
Q9WTN6	—	0.990	Q9WTN6 →
O02713	—	0.989	O02713 →
O08966	—	0.988	O08966 →
O77504	—	0.988	O77504 →
Q5R5H7	—	0.988	Q5R5H7 →
SLC22A2	Solute carrier family 22 member 2	0.987	landscape →
O70577	—	0.986	O70577 →
O88446	—	0.986	O88446 →
SLC22A3	Solute carrier family 22 member 3	0.984	landscape →
Q63089	—	0.984	Q63089 →
Q9WTW5	—	0.983	Q9WTW5 →
SLC22A1	Solute carrier family 22 member 1	0.983	landscape →
Q863T6	—	0.983	Q863T6 →
Q91WU2	—	0.983	Q91WU2 →
Q9VCA2	—	0.981	Q9VCA2 →
A7MBE0	—	0.981	A7MBE0 →
O57379	—	0.981	O57379 →
B2GV36	—	0.980	B2GV36 →
Q9Y226	—	0.980	Q9Y226 →
Q66J54	—	0.979	Q66J54 →
Q9R1U7	—	0.978	Q9R1U7 →
Q28ES4	—	0.978	Q28ES4 →