Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 8/20 | 0.62 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.62 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2367383 | 0.83 | NR3C1 (0.65) | SLC40A1GLO1NR3C1PGRNR3C2 | |
| SCHEMBL3060588 | 0.80 | GAA (0.57) | SLC40A1GLO1NR3C1PGRNR3C2 | |
| SCHEMBL3066019 | 0.77 | SLC40A1 (0.57) | SLC40A1NR3C1PGRNR3C2AR | |
| SCHEMBL2367682 | 0.77 | NR3C1 (0.64) | SLC40A1NR3C1PGRNR3C2AR | |
| SCHEMBL30925462 | 0.77 | SLC40A1 (1.00) | SLC40A1GLO1G6PDNFKBIAAGTR1 | |
| SCHEMBL2367735 | 0.77 | NR3C1 (0.60) | SLC40A1NR3C1PGRNR3C2AR | |
| SCHEMBL1984869 | 0.77 | CA1 (0.60) | NR3C1PGRNR3C2ARTDP1 | |
| SCHEMBL11973652 | 0.77 | SLC40A1 (1.00) | SLC40A1GLO1G6PDNFKBIAAGTR1 | |
| SCHEMBL2367583 | 0.74 | NFKBIA (0.58) | NR3C1PGRNR3C2ARNFKBIA | |
| SCHEMBL3061760 | 0.74 | NR3C1 (0.56) | NR3C1PGRNR3C2ARKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210387949-A1 | NEW SELECTIVE MODULATORS OF INSECT NICOTINIC ACETYLCHOLINE RECEPTORS | UNIV NANTES (FR) | 2021-12-16 | — | — | US | disclosed |
| CN-113631551-A | Novel competitive modulators of insect nicotinic acetylcholine receptors | 南特大学 | 2021-11-09 | — | — | CN | disclosed |
| EP-3877377-A1 | NEW SELECTIVE MODULATORS OF INSECT NICOTINIC ACETYLCHOLINE RECEPTORS | Universite de Nantes (FR) | 2021-09-15 | — | — | EP | disclosed |
| EP-3650447-A1 | NEW SELECTIVE MODULATORS OF INSECT NICOTINIC ACETYLCHOLINE RECEPTORS | Universite de Nantes (FR) | 2020-05-13 | — | — | EP | disclosed |
| US-7939532-B2 | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-7879884-B2 | 6-(2-Chloro-phenyl)-5-methyl-pyridine-3-sulfonic acid 2-chloro-4-fluoro-benzoylamide; potassium salt, used as antiproliferative, anticarcinogenic or antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 2011-02-01 | — | — | US | disclosed |
| US-20100292247-A1 | HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-18 | — | — | US | disclosed |
| US-20100256200-A1 | ARYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-07 | — | — | US | disclosed |
| EP-2148861-A1 | ARYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| US-7625896-B2 | Pyridylsulfonamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-12-01 | — | — | US | disclosed |
| WO-2008138594-A1 | ARYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |
| EP-1960361-A1 | PYRIDYLSULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTINEOPLASTIC AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007059872-A1 | PYRIDYLSULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS ANTINEOPLASTIC AGENTS | F. HOFFMNN-LA ROCHE AG (CH) | 2007-05-31 | — | — | WO | disclosed |
| US-20070123513-A1 | 6-thiomorpholin-4-yl-pyridine-3-sulfonic acid 4-chloro-2-methoxy-benzoylamide; ammonium salt of3-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-sulfonic acid 4-chloro-2-methoxy-benzoylamide; anticarcinogenic agent | HOFFMANN-LA ROCHE INC. | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123513-A1 | 6-thiomorpholin-4-yl-pyridine-3-sulfonic acid 4-chloro-2-methoxy-benzoylamide; ammonium salt of3-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-sulfonic acid 4-chloro-2-methoxy-benzoylamide; anticarcinogenic agent | TPMT, BPNT1, SLC6A3 | SLC40A1 2750/4885GLO1 1104/4885NR3C1 775/4885 |
| US-20100256200-A1 | ARYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | ARSA, STS, SULT2A1 | SLC40A1 1296/4885GLO1 1605/4885NR3C1 3269/4885 |
| US-20210387949-A1 | NEW SELECTIVE MODULATORS OF INSECT NICOTINIC ACETYLCHOLINE RECEPTORS | CHRM3, CHRNA3, CHRNB3 | SLC40A1 3203/4885GLO1 1819/4885NR3C1 468/4885 |
| US-20100292247-A1 | HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | STS, TPMT, DPYD | SLC40A1 2677/4885GLO1 2248/4885NR3C1 4159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.