Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.73 |
| ▸ | GLO1 | Q04760 | 3/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | SLC40A1 | Q9NP59 | 10/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.54 |
| ▸ | G6PD | P11413 | 1/20 | 0.53 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4466489 | 0.88 | SLC40A1 (0.74) | MEN1KMT2ATDP1GLO1POLB | |
| SCHEMBL6979087 | 0.84 | TDP1 (1.00) | MEN1KMT2ATDP1GLO1POLB | |
| SCHEMBL22076984 | 0.83 | MEN1 (1.00) | MEN1KMT2ATDP1GLO1POLB | |
| SCHEMBL8583772 | 0.76 | TDP1 (0.82) | MEN1KMT2ATDP1GLO1POLB | |
| SCHEMBL16187973 | 0.76 | MMP2 (0.73) | MEN1KMT2ATDP1GLO1POLB | |
| SCHEMBL6980652 | 0.75 | TDP1 (0.76) | MEN1KMT2ATDP1GLO1SLC40A1 | |
| SCHEMBL3825367 | 0.75 | TDP1 (1.00) | MEN1KMT2ATDP1GLO1SLC40A1 | |
| SCHEMBL11972974 | 0.74 | SLC40A1 (1.00) | TDP1GLO1SLC40A1AGTR1HSP90AA1 | |
| SCHEMBL23413185 | 0.73 | MEN1 (0.67) | MEN1KMT2ATDP1GLO1POLB | |
| SCHEMBL30092884 | 0.73 | MEN1 (0.67) | MEN1KMT2ATDP1GLO1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275165-A1 | COMPOUNDS THAT INHIBIT NFkB AND BACE1 ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275165-A1 | COMPOUNDS THAT INHIBIT NFkB AND BACE1 ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-09-18 | — | — | US | disclosed |
| US-20120064099-A1 | COMPOUNDS THAT INHIBIT NFKB AND BACE1 ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-03-15 | — | — | US | disclosed |
| US-20120064099-A1 | COMPOUNDS THAT INHIBIT NFKB AND BACE1 ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275165-A1 | COMPOUNDS THAT INHIBIT NFkB AND BACE1 ACTIVITY | NFKBIA, BACE1, BACE2 | MEN1 4238/4885KMT2A 2785/4885TDP1 567/4885 |
| US-20120064099-A1 | COMPOUNDS THAT INHIBIT NFKB AND BACE1 ACTIVITY | NFKBIA, BACE1, BACE2 | MEN1 4238/4885KMT2A 2785/4885TDP1 567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.