SPIN4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL29369030	1.00	1/20
SCHEMBL19385205	0.58	1/20
SCHEMBL29937017	0.58	1/20
SCHEMBL2953260	0.56	1/20
SCHEMBL28894304	0.55	1/20
SCHEMBL19385373	0.55	1/20
SCHEMBL1089104	0.55	1/20
SCHEMBL1089641	0.54	1/20
SCHEMBL1089644	0.54	1/20
SCHEMBL1090089	0.54	1/20
SCHEMBL19385129	0.53	1/20
SCHEMBL25244226	0.53	1/20
SCHEMBL28894334	0.53	1/20
SCHEMBL19385236	0.52	1/20
SCHEMBL19385261	0.52	1/20
SCHEMBL19405236	0.52	1/20
SCHEMBL25202485	0.52	1/20
SCHEMBL19385009	0.52	1/20
SCHEMBL23015382	0.51	1/20
SCHEMBL19385024	0.51	1/20

Clinical trials — most relevant to SPIN4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment	PHASE2/PHASE3	RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)	PHASE1/PHASE2	NOT_YET_RECRUITING
Phase I Study of SC-43 Oral Solution in Subjects With Refractory Solid Tumors	PHASE1	WITHDRAWN
Hemolysis in Patients With Hereditary Spherocytosis (HS)	nan	UNKNOWN
Risk of Ovarian Cancer in Patients With a Pelvic Mass	nan	COMPLETED
Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility	nan	COMPLETED
Circulating Cell-free DNA-based Epigenetic Biomarker mSEPT9 for Hepatocellular Carcinoma Detection in Cirrhosis	nan	COMPLETED
Efficacy of Cognitive Rehabilitation Using Virtual Reality and Computer-based Cognitive Stimulation on Cognitive Impairment Associated to Movement Disorders	nan	COMPLETED
Genetic Investigation of Solid Tumors Cohort	nan	COMPLETED
New Genes in the Carcinogenesis of Colorectal Cancer	nan	UNKNOWN
Consequences of Mutations in the SPG7 Gene at the Heterozygous State	nan	COMPLETED
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing	nan	RECRUITING
DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings	nan	COMPLETED
A Positional Cloning Study on Schizophrenia	nan	COMPLETED
Adrenal& Bone Complications in Paediatric Patients Living With Spinal Muscular Atrophy (SMA)	nan	NOT_YET_RECRUITING
Susceptibility Genes in Autism Spectrum Disorders	nan	COMPLETED
Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors	nan	COMPLETED
A Clinical Study on the Safety and Efficacy of CAR-T Therapy for the TM4SF1- and EpCAM-positive Solid Tumors	nan	UNKNOWN
Implementation of FEES in Spinal Muscle Atrophy	nan	COMPLETED
Mechanisms of Cell Death in Spinal Muscular Atrophy	nan	COMPLETED
Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral Sclerosis	nan	COMPLETED
The Natural History of Patients With Mutations in SEPN1 (SELENON) or LAMA2	nan	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Improving Genetic Counseling for Patients With Spina Bifida Using Next Generation Sequencing	nan	COMPLETED
The Role of HE4 in the Follow-up of Advanced Ovarian, Fallopian Tube and Primary Peritoneal Cancer	nan	UNKNOWN
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Study of Genotype and Phenotype Characterization in Duchenne Muscular Dystrophy With Small Mutations	nan	UNKNOWN
VRehab-SMA Phase 1.2	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a SPIN4 binder may also engage these)

Protein	Name	Similarity
Q8K1L2	—	1.000	Q8K1L2 →
Q6NVE3	—	0.989	Q6NVE3 →
Q2KI39	—	0.986	Q2KI39 →
P13675	—	0.975	P13675 →
Q6YVY0	—	0.970	Q6YVY0 →
Q32N90	—	0.969	Q32N90 →
Q6DIN3	—	0.968	Q6DIN3 →
Q9ZPY6	—	0.966	Q9ZPY6 →
Q9XED8	—	0.966	Q9XED8 →
Q9C516	—	0.966	Q9C516 →
MBTD1	MBT domain-containing protein 1	0.965	landscape →
Q9XID4	—	0.963	Q9XID4 →
Q8L7G0	—	0.963	Q8L7G0 →
Q9LQE3	—	0.963	Q9LQE3 →
P59178	—	0.960	P59178 →
Q9FWS6	—	0.960	Q9FWS6 →
Q9C5W9	—	0.960	Q9C5W9 →
Q5R737	—	0.960	Q5R737 →
C0SUW7	—	0.960	C0SUW7 →
O80462	—	0.960	O80462 →
Q5DTW2	—	0.960	Q5DTW2 →
Q93VH2	—	0.959	Q93VH2 →
Q3MIF2	—	0.959	Q3MIF2 →
Q9BXT6	—	0.959	Q9BXT6 →
P0C7Q8	—	0.958	P0C7Q8 →
MAP3K5	Mitogen-activated protein kinase kinase kinase 5	0.958	landscape →
Q8W4F0	—	0.958	Q8W4F0 →
Q9SFW8	—	0.958	Q9SFW8 →
Q5JK20	—	0.958	Q5JK20 →
Q8NE18	—	0.958	Q8NE18 →