SCHEMBL178745

SCHEMBL178745

O=C1[C@H](Cc2ccc(O)cc2)N2C(=O)CCN(C(=O)NCc3ccccc3)[C@H]2CN1Cc1cccc2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CLPP Q16740 19/20 1.00
CTNNB1 P35222 2/20 1.00
TCF7 P36402 2/20 1.00
BCL9 O00512 1/20 1.00
TCF4 P15884 1/20 1.00
CREBBP Q92793 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19833048 1.00 CLPP (1.00) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL13744871 1.00 CLPP (1.00) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL4865605 1.00 CLPP (1.00) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL15677335 1.00 CLPP (1.00) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL4865597 1.00 CLPP (1.00) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL29352986 1.00 CLPP (1.00) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL15677334 0.96 CLPP (1.00) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL18699677 0.96 CLPP (1.00) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL19833044 0.94 CLPP (0.92) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL20752946 0.94 CLPP (0.92) CLPPCTNNB1TCF7BCL9TCF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210379021-A1 METHOD FOR PREPARING AND DELIVERING BISANTRENE FORMULATIONS RACE ONCOLOGY LTD (AU) 2021-12-09 US claimed
EP-3311841-B1 ANTICANCER AGENT PRISM BIOLAB CO LTD (JP) 2021-07-28 EP claimed
WO-2020068665-A1 USE OF COLLAGEN BINDING DOMAINS TO DELIVER PRODUCTS TO SKIN FABIUS BIOTECHNOLOGY (US) 2020-04-02 WO claimed
US-20180185395-A1 ANTICANCER AGENT PRISM PHARMA CO., LTD. (JP) 2018-07-05 US claimed
US-20160303137-A1 DUAL PI3K AND WNT PATHWAY INHIBITION AS A TREATMENT FOR CANCER INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION 2016-10-20 US claimed
WO-2024113351-A1 CULTURE MEDIUM, COATING MATRIX AND METHOD FOR MATURING MIDBRAIN DOPAMINERGIC PROGENITOR CELLS NUWACELL BIOTECHNOLOGIES CO., LTD. (CN) 2024-06-06 WO disclosed
WO-2024113354-A1 CULTURE MEDIUM, COATING MATRIX AND METHOD FOR EXPANDING MIDBRAIN DOPAMINERGIC PROGENITOR CELLS NUWACELL BIOTECHNOLOGIES CO., LTD. (CN) 2024-06-06 WO disclosed
EP-2958571-B1 DNA HYPOMETHYLATING AGENTS FOR CANCER THERAPY MAIO MICHELE (IT) 2024-04-10 EP disclosed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230285498-A1 TREATMENTS FOR CANCERS HAVING KRAS MUTATIONS CITY OF HOPE 2023-09-14 US disclosed
US-20230272347-A1 Differentiation Method KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN (NL) 2023-08-31 US disclosed
US-20230272347-A1 Differentiation Method KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN (NL) 2023-08-31 US disclosed
US-20080153743-A1 METHODS RELATING TO THE TREATMENT OF FIBROSIS UNIVERSITY OF WASHINGTON (US) 2008-06-26 US disclosed
US-20080153743-A1 METHODS RELATING TO THE TREATMENT OF FIBROSIS UNIVERSITY OF WASHINGTON (US) 2008-06-26 US disclosed
US-7345040-B2 Reverse-turn mimetics and compositions and methods relating thereto MYRIAD GENETICS, INC. (US) 2008-03-18 US disclosed
US-7345040-B2 Reverse-turn mimetics and compositions and methods relating thereto MYRIAD GENETICS, INC. (US) 2008-03-18 US disclosed
US-7232822-B2 Reverse-turn mimetics and method relating thereto CHOONGWAE PHARMA CORPORATION (KR) 2007-06-19 US disclosed
US-7232822-B2 Reverse-turn mimetics and method relating thereto CHOONGWAE PHARMA CORPORATION (KR) 2007-06-19 US disclosed
US-20070021425-A1 Reverse-turn mimetics and method relating thereto CHOONGWAE PHARMA CORPORATION (KR) 2007-01-25 US disclosed
US-20070021425-A1 Reverse-turn mimetics and method relating thereto CHOONGWAE PHARMA CORPORATION (KR) 2007-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230272347-A1 Differentiation Method MYADM, EPCAM, MCL1 CLPP 4481/4885CTNNB1 170/4885TCF7 238/4885
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 CLPP 2852/4885CTNNB1 2729/4885TCF7 1631/4885
US-20080153743-A1 METHODS RELATING TO THE TREATMENT OF FIBROSIS CFTR, EDNRB, COL1A1 CLPP 3294/4885CTNNB1 1287/4885TCF7 1888/4885
US-20210379021-A1 METHOD FOR PREPARING AND DELIVERING BISANTRENE FORMULATIONS CYP3A43, CYP1A1, UGT1A3 CLPP 3298/4885CTNNB1 1181/4885TCF7 2885/4885
US-20070021425-A1 Reverse-turn mimetics and method relating thereto WNT1, APC, WNT3 CLPP 4096/4885CTNNB1 14/4885TCF7 49/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.