Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | TERF2 | Q15554 | 8/20 | 0.39 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290665 | 0.86 | GAA (0.42) | GAAPPIACTSDTERF2PSMB9 | |
| SCHEMBL12607418 | 0.82 | GAA (0.38) | GAAPPIACTSD | |
| SCHEMBL8290330 | 0.82 | CAPN2 (0.37) | GAA | |
| SCHEMBL12856032 | 0.81 | PPIA (0.38) | GAAPPIACTSDTERF2PSMB9 | |
| SCHEMBL8291664 | 0.77 | CTSD (0.40) | GAAPPIACTSDTERF2PSMB9 | |
| SCHEMBL8193266 | 0.75 | PPIA (0.34) | GAAPPIACTSDTERF2PSMB9 | |
| SCHEMBL16349811 | 0.74 | F2 (0.42) | GAATERF2HDAC4HDAC1 | |
| SCHEMBL8291443 | 0.73 | F2 (0.43) | GAATERF2HDAC4HDAC1 | |
| SCHEMBL8291503 | 0.72 | F2 (0.41) | GAATERF2HDAC4HDAC1 | |
| SCHEMBL8006720 | 0.72 | TERF2 (0.33) | GAACTSDTERF2HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664092-B1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE | SCHERING CORP (US) | 2011-02-02 | — | — | EP | disclosed |