Sugi Predict
/ Targets
/ TPP1
Top predicted compounds (top 20 by supporting neighbours, then confidence)
Clinical trials — most relevant to TPP1 by text similarity (a relevance ranking, not an exhaustive list)
| Trial | Phase | Status |
|---|
| The Effect of Sitagliptin, Pioglitazone and Dapagliflozine on Myocardial Infarction in Diabetic Rats |
PHASE4 | COMPLETED |
| Effect of Sitagliptin and an ACE Inhibitor on Blood Pressure in Metabolic Syndrome |
PHASE4 | COMPLETED |
| Cystagon to Treat Infantile Neuronal Ceroid Lipofuscinosis |
PHASE4 | COMPLETED |
| The Effects of Neprilysin on Glucagon-like Peptide-1 |
PHASE4 | COMPLETED |
| SNP Study of DPP-4 and GLP-1R in Chinese People (Including Diabetes Patients) |
PHASE4 | COMPLETED |
| Study of the QOL Evaluation of Trelagliptin in Patients With Type 2 Diabetes Mellitus |
PHASE4 | COMPLETED |
| Atazanavir and Endothelial Function in Older HIV Patients |
PHASE2/PHASE3 | COMPLETED |
| Comparison Between Efficacy of Trelagliptin and Sitagliptin in Type II Diabetic Patients |
PHASE3 | ENROLLING_BY_INVITATION |
| Sitagliptin and Endothelial Dysfunction |
PHASE3 | UNKNOWN |
| A Phase 3, Randomized, Double-blind, Parallel-group, Comparative Study and a Phase 3, Multicenter, Open-label, Long-term Study of SYR-472 (25 mg) in Patients With Type 2 Diabetes Mellitus Complicated by Severe Renal Impairment or End-stage Renal Disease |
PHASE3 | COMPLETED |
| Saxagliptin + Metformin Compared to Saxagliptin or Metformin Monotherapy in PCOS Women With Impaired Glucose Homeostasis |
PHASE3 | COMPLETED |
| Quantification of the Dipeptidyl Peptidase (DPP)-4 Inhibition-mediated Enhancement of the Activity of the Entero-insular Axis |
PHASE2/PHASE3 | COMPLETED |
| A Phase 1/2 Open-Label Dose-Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Efficacy of Intracerebroventricular BMN 190 in Patients With Late-Infantile Neuronal Ceroid Lipofuscinosis (CLN2) Disease |
PHASE1/PHASE2 | COMPLETED |
| A First-in-Human, Open-Label, Dose-Escalation Study to Evaluate the Safety and Tolerability of Gene Therapy With TTX-381 for the Ocular Manifestations Associated With Neuronal Ceroid Lipofuscinosis Type 2 (CLN2) Disease |
PHASE1/PHASE2 | RECRUITING |
| Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus |
PHASE2 | COMPLETED |
| An Extension Study to Evaluate the Long-Term Efficacy and Safety of BMN 190 in Patients With CLN2 Disease |
PHASE1/PHASE2 | COMPLETED |
| Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus |
PHASE2 | COMPLETED |
| Effect of Evogliptin on Albuminuria in Patients With Type 2 Diabetes and Renal Insufficiency |
PHASE2 | COMPLETED |
| Study of HuCNS-SC Cells in Patients With Infantile or Late Infantile Neuronal Ceroid Lipofuscinosis (NCL) |
PHASE1 | COMPLETED |
| Safety Study of a Gene Transfer Vector for Children With Late Infantile Neuronal Ceroid Lipofuscinosis |
PHASE1 | COMPLETED |
| Effect of Sitagliptin on Incretin Effect in Patients With Type 2 Diabetes Mellitus |
PHASE1 | COMPLETED |
| Longitudinal Assessment of Atypical Tripeptidyl Peptidase 1 Enzyme Deficiency Patients |
nan | ACTIVE_NOT_RECRUITING |
| Genetic and Morphological Analysis of Thyrotoxic Periodic Paralysis |
nan | UNKNOWN |
| Genetic Analysis of Thyrotoxic Periodic Paralysis |
nan | COMPLETED |
| DPP4 Activity, Microvascular Reactivity and Inflammation |
nan | COMPLETED |
| Influence of DPP-4 on Inflammatory Parameters in Diabetics: Gender Aspects |
nan | UNKNOWN |
| Effect of Dipeptidyl Peptidase IV After Diets in näive Type 2 Diabetic Patients |
nan | COMPLETED |
| A Pilot Study to Evaluate the Glucagon-Like Peptide 1 Response to the Challenge of Mixed Meals in Chinese Subjects |
nan | COMPLETED |
| Genetic Studies of Lysosomal Storage Disorders |
nan | ENROLLING_BY_INVITATION |
| A Multicenter, Multi-national Open-label Program to Provide BMN 190 to Patients Diagnosed With CLN2 Disease |
nan | APPROVED_FOR_MARKETING |
Related proteins — ESM-2 sequence neighbours (a TPP1 binder may also engage these)