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Sugi Predict / Targets / PLD3

PLD3

5'-3' exonuclease PLD3 · Q8IV08 · PLD3 on Sugi Atlas →

110 patent compounds predicted against PLD3, 92 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL8291374 SCHEMBL8291374 0.81 1/20
SCHEMBL29517871 SCHEMBL29517871 0.73 1/20
SCHEMBL16029403 SCHEMBL16029403 0.65 1/20
SCHEMBL16664758 SCHEMBL16664758 0.64 1/20
SCHEMBL14285657 SCHEMBL14285657 0.61 1/20
SCHEMBL18834904 SCHEMBL18834904 0.61 1/20
SCHEMBL23493869 SCHEMBL23493869 0.58 1/20
SCHEMBL16029594 SCHEMBL16029594 0.57 1/20
SCHEMBL3372363 SCHEMBL3372363 0.57 1/20
SCHEMBL16029556 SCHEMBL16029556 0.56 1/20
SCHEMBL662570 SCHEMBL662570 0.56 1/20
SCHEMBL16030391 SCHEMBL16030391 0.55 1/20
SCHEMBL16059176 SCHEMBL16059176 0.55 1/20
SCHEMBL16133944 SCHEMBL16133944 0.55 1/20
SCHEMBL19771398 SCHEMBL19771398 0.55 1/20
SCHEMBL16079530 SCHEMBL16079530 0.55 1/20
SCHEMBL16029479 SCHEMBL16029479 0.55 1/20
SCHEMBL13938943 SCHEMBL13938943 0.54 1/20
SCHEMBL19560565 SCHEMBL19560565 0.54 1/20
SCHEMBL661222 SCHEMBL661222 0.54 1/20

Clinical trials — most relevant to PLD3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients PHASE2COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
PET Imaging of DHA Metabolism nanCOMPLETED
Molecular Markers of Human Sperm Function nanWITHDRAWN
the Role of plin5 in the Development of Nonalcoholic Fatty Liver Disease. nanUNKNOWN
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects) nanUNKNOWN
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations nanCOMPLETED
Investigation of Copy Number Variations and Genetic Variants in POI nanRECRUITING
The Efficacy of Pedometer-motivated Physical Activity for the Management of Patients With MASLD. nanENROLLING_BY_INVITATION
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve nanUNKNOWN
Identification of an Asthma Susceptibility Gene on 3P nanCOMPLETED
PCD New Gene Discovery nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma nanRECRUITING
Genetic Investigation of Cancer Predisposition nanNOT_YET_RECRUITING
Prospective Genetic Study in Patients With Ovarian Insufficiency nanUNKNOWN
Mucomyst for Hepatitis C nanSUSPENDED
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage nanENROLLING_BY_INVITATION
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity. nanCOMPLETED
Identification of a New Gene Involved in Hereditary Lipodystrophy nanCOMPLETED
Genetics and Psychopathology in the 22q11 Deletion Syndrome nanUNKNOWN
Weathering the Storm: Lung, Heart, and Brain Vascular Rehabilitation for COVID-19 nanUNKNOWN
Screening for Early Pancreatic Neoplasia (Cancer of the Pancreas Screening or CAPS4 Study) nanCOMPLETED
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia nanUNKNOWN
Chromosome 5Q Gene Variants and Asthma-Related Traits nanCOMPLETED
Pheno- & Genotyping POF (WHO III) nanUNKNOWN
Genetics of Primary Ciliary Dyskinesia nanCOMPLETED
Diagnosis of Primary Ciliary Dyskinesia nanCOMPLETED
Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus nanACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a PLD3 binder may also engage these)

ProteinNameSimilarity
Q5FVH2 — 1.000 Q5FVH2 →
O35405 — 1.000 O35405 →
Q2KJJ8 — 1.000 Q2KJJ8 →
Q4R583 — 1.000 Q4R583 →
Q5R4Y7 — 1.000 Q5R4Y7 →
Q8BG07 — 0.993 Q8BG07 →
Q6PB03 — 0.992 Q6PB03 →
PLD4 5'-3' exonuclease PLD4 0.988 landscape →
P97813 — 0.983 P97813 →
Q3UNN8 — 0.978 Q3UNN8 →
Q640B3 — 0.978 Q640B3 →
PLD2 Phospholipase D2 0.977 landscape →
Q8N7P1 — 0.977 Q8N7P1 →
Q5FVF9 — 0.976 Q5FVF9 →
P70498 — 0.975 P70498 →
A6QQ07 — 0.975 A6QQ07 →
A1L1C2 — 0.974 A1L1C2 →
Q28193 — 0.973 Q28193 →
Q5R5N6 — 0.973 Q5R5N6 →
Q29052 — 0.972 Q29052 →
Q0V8L6 — 0.972 Q0V8L6 →
O17405 — 0.972 O17405 →
Q8VDP3 — 0.972 Q8VDP3 →
Q7Z4N8 — 0.972 Q7Z4N8 →
Q69ZQ1 — 0.972 Q69ZQ1 →
Q9M9W8 — 0.971 Q9M9W8 →
Q8CFX1 — 0.971 Q8CFX1 →
A4FUH1 — 0.971 A4FUH1 →
Q5R8R3 — 0.971 Q5R8R3 →
A3KNW0 — 0.971 A3KNW0 →