TRIB2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL24376312	0.88	1/20
SCHEMBL30293601	0.68	1/20
SCHEMBL30293626	0.68	1/20
SCHEMBL24376532	0.66	1/20
SCHEMBL24376319	0.64	1/20
SCHEMBL24376342	0.64	1/20
SCHEMBL24376425	0.64	1/20
SCHEMBL24376457	0.64	1/20
SCHEMBL29622114	0.64	1/20
SCHEMBL29622426	0.64	1/20
SCHEMBL24376374	0.63	1/20
SCHEMBL29622188	0.63	1/20
SCHEMBL30704496	0.63	1/20
SCHEMBL24376311	0.63	1/20
SCHEMBL30293563	0.63	1/20
SCHEMBL23559618	0.63	1/20
SCHEMBL24376413	0.62	1/20
SCHEMBL24376498	0.62	1/20
SCHEMBL29622153	0.62	1/20
SCHEMBL24376332	0.62	1/20

Clinical trials — most relevant to TRIB2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Tributyrin Supplementation on Glycemic Control, Inflammation, and Cardiovascular Risk in Patients With Type 2 Diabetes	PHASE3	NOT_YET_RECRUITING
Gemcitabine Hydrochloride and Oxaliplatin or Observation in Treating Patients With Biliary Tract Cancer That Has Been Removed by Surgery	PHASE3	COMPLETED
Signal TrAnsduction Pathway Activity Analysis in OVarian cancER	PHASE2/PHASE3	RECRUITING
LY3022855 With BRAF/MEK Inhibition in Patients With Melanoma	PHASE1/PHASE2	COMPLETED
Phase II Study of Metformin for Reduction of Obesity-Associated Breast Cancer Risk	PHASE2	COMPLETED
MCS110 With BRAF/MEK Inhibition in Patients With Melanoma	PHASE1/PHASE2	COMPLETED
Phase I-II Everolimus and Sorafenib in Recurrent High-Grade Gliomas	PHASE1/PHASE2	COMPLETED
Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans	PHASE1	COMPLETED
Obinutuzumab in Combination With Venetoclax in Previously Untreated Follicular Lymphoma Patients	PHASE1	COMPLETED
Concentration and Activity of Lapatinib in Vestibular Schwannomas	EARLY_PHASE1	COMPLETED
Expression and Function of the Renin-Angiotensin System in the Esophagus	EARLY_PHASE1	COMPLETED
Value of MicroRNA30a in Philadelphia Positive Leukemic Patients	nan	UNKNOWN
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Gene Expression and Inflammation in Overweight Subjects	nan	COMPLETED
Gene Expression in Obesity and Insulin Resistance	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
A Study of Serum Protein Profiling in Patients With Non-Small Cell Lung Cancer Treated With Gefitinib or Erlotinib	nan	COMPLETED
Gene-Specific Responses to Exercise in Discordant Twins	nan	COMPLETED
Small Extracellular Vesicles and Insulin Action	nan	RECRUITING
Genomic Landscape of Intramedullary Astrocytoma	nan	UNKNOWN
for Adipose Tissue DIabetes VAriants (fATDIVA)	nan	COMPLETED
The Influence of Autophagy on Fatty Liver	nan	UNKNOWN
Re-energize With Nutrition, Exercise and Weight Loss	nan	COMPLETED
Omics-based Predictors of NAFLD/Potential NASH	nan	UNKNOWN
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Prognostic Value of Protein IMP3 Expression in Cervical Cancer	nan	COMPLETED
Beige Fat, Energy, and the Natriuretic Peptide System	nan	COMPLETED
Autophagy Bladder Cancer	nan	UNKNOWN
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise	nan	COMPLETED
The Effect Of DAAs on miRNA-122 And Insulin Resistance In Chronic HCV Patients	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a TRIB2 binder may also engage these)

Protein	Name	Similarity
Q5R669	—	1.000	Q5R669 →
Q5GLH2	—	1.000	Q5GLH2 →
Q28283	—	1.000	Q28283 →
Q8K4K3	—	1.000	Q8K4K3 →
Q7TNL3	—	0.991	Q7TNL3 →
Q66I46	—	0.990	Q66I46 →
Q7TNL4	—	0.990	Q7TNL4 →
Q17QV9	—	0.989	Q17QV9 →
Q8K4K4	—	0.987	Q8K4K4 →
Q8W4L3	—	0.987	Q8W4L3 →
Q8W490	—	0.987	Q8W490 →
Q9FHD7	—	0.987	Q9FHD7 →
Q9LET1	—	0.987	Q9LET1 →
Q7T0B0	—	0.987	Q7T0B0 →
Q6P431	—	0.986	Q6P431 →
Q9LX30	—	0.986	Q9LX30 →
Q94C95	—	0.986	Q94C95 →
Q62074	—	0.986	Q62074 →
Q9LS26	—	0.986	Q9LS26 →
Q5R667	—	0.986	Q5R667 →
Q02956	—	0.986	Q02956 →
F4I7Y4	—	0.986	F4I7Y4 →
P0DH62	—	0.986	P0DH62 →
PRKCZ	Protein kinase C zeta type	0.985	landscape →
F1M7Y5	—	0.985	F1M7Y5 →
O80673	—	0.985	O80673 →
Q8K4K2	—	0.985	Q8K4K2 →
TRIB1	Tribbles homolog 1	0.985	landscape →
O22243	—	0.985	O22243 →
Q7T0B1	—	0.985	Q7T0B1 →