Gambogic Acid

Gambogic Acid

SCHEMBL3857525

CC(C)=CCC[C@]1(C)C=Cc2c(O)c3c(c(CC=C(C)C)c2O1)O[C@]12C(=CC4CC1C(C)(C)OC2(C/C=C(/C)C(=O)O)C4=O)C3=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 6/20 1.00
MAPT P10636 6/20 1.00
MAPK1 P28482 6/20 1.00
HSD17B10 Q99714 6/20 1.00
PTPN1 P18031 6/20 1.00
CYP3A4 P08684 5/20 1.00
SMN1; SMN2 Q16637 5/20 1.00
ALOX15 P16050 5/20 1.00
HPGD P15428 3/20 1.00
BLM P54132 3/20 1.00
KDM4E B2RXH2 3/20 1.00
IKBKB O14920 3/20 1.00
HSP90AA1 P07900 1/20 1.00
HSP90AB1 P08238 1/20 1.00
BCL2 P10415 1/20 1.00
TXN P10599 1/20 1.00
BCL2L1 Q07817 1/20 1.00
MCL1 Q07820 1/20 1.00
BCL2A1 Q16548 1/20 1.00
SPTSSB Q8NFR3 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gambogic Acid SCHEMBL12751296 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL13613351 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL13685812 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL12025387 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL12025441 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL12045553 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL24089082 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL12026374 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL16160279 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL12045554 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013067543-A1 METHODS AND COMPOSITIONS FOR ADMINISTERING A SPECIFIC WAVELENGTH PHOTOTHERAPY FOLLEA INTERNATIONAL LTD. (CN) 2013-05-10 WO claimed
US-20130115180-A1 Methods And Compositions For Administering A Specific Wavelength Phototherapy APPLIED BIOLOGY, INC. 2013-05-09 US claimed
WO-2025064402-A1 METHOD FOR TREATING SICKLE CELL DISEASE BY TARGETING SENESCENT CELLS ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (US) 2025-03-27 WO disclosed
US-20250041294-A1 Synergistic compositions for use in the treatment of cancer SARTAR THERAPEUTICS OY (FI) 2025-02-06 US disclosed
EP-4444314-A1 SYNERGISTIC COMPOSITIONS FOR USE IN THE TREATMENT OF CANCER Sartar Therapeutics Oy (FI) 2024-10-16 EP disclosed
US-20240316060-A1 LASER AND BCL-2 INHIBITORS COMBINATION TO TREAT SOLID TUMORS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2024-09-26 US disclosed
CN-118354773-A Synergistic composition for the treatment of cancer 萨达治疗公司 2024-07-16 CN disclosed
CN-117603669-B Comprehensive blocking remover for oil, gas and water wells and use method thereof 北京石大瑞伽石油技术开发有限公司 2024-04-19 CN disclosed
CN-117603669-A Comprehensive blocking remover for oil, gas and water wells and use method thereof 北京石大瑞伽石油技术开发有限公司 2024-02-27 CN disclosed
CN-116602955-A GPR108 inhibitor application 上海中医药大学 2023-08-18 CN disclosed
WO-2023105119-A1 SYNERGISTIC COMPOSITIONS FOR USE IN THE TREATMENT OF CANCER SARTAR THERAPEUTICS OY (FI) 2023-06-15 WO disclosed
US-10111821-B2 Methods and compositions for administering a specific wavelength phototherapy APPLIED BIOLOGY, INC. (US) 2018-10-30 US disclosed
WO-2015103012-A1 METHODS AND COMPOSITIONS FOR ADMINISTERING A SPECIFIC WAVELENGTH PHOTOTHERAPY APPLIED BIOLOGY, INC. (US) 2015-07-09 WO disclosed
WO-2014070266-A1 COMPOSITIONS FOR ADMINISTERING A SPECIFIC WAVELENGTH PHOTOTHERAPY GLOBAL LIFE SCIENCE PARTNERS LIMITED (CN) 2014-05-08 WO disclosed
US-20140121732-A1 METHODS AND COMPOSITIONS FOR ADMINISTERING A SPECIFIC WAVELENGTH PHOTOTHERAPY APPLIED BIOLOGY, INC. (US) 2014-05-01 US disclosed
US-20130310730-A1 Methods And Compositions For Administering A Specific Wavelength Phototherapy APPLIED BIOLOGY, INC. (US) 2013-11-21 US disclosed
WO-2013067543-A1 METHODS AND COMPOSITIONS FOR ADMINISTERING A SPECIFIC WAVELENGTH PHOTOTHERAPY FOLLEA INTERNATIONAL LTD. (CN) 2013-05-10 WO disclosed
US-20130115180-A1 Methods And Compositions For Administering A Specific Wavelength Phototherapy APPLIED BIOLOGY, INC. 2013-05-09 US disclosed
US-7592367-B2 Compounds from Garcinia hanburyi, their use in treating cancer and method of separating epimers thereof HONG KONG JOCKEY CLUB INSTITUTE OF CHINESE MEDICINE LTD. (CN) 2009-09-22 US disclosed
US-20070149610-A1 NOVEL COMPOUNDS FROM GARCINIA HANBURYI, THEIR USE IN TREATING CANCER AND METHOD OF SEPARATING EPIMERS THEREOF HONG KONG JOCKEY CLUB INSTITUTE OF CHINESE MEDICINE LIMITED (CN) 2007-06-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070149610-A1 NOVEL COMPOUNDS FROM GARCINIA HANBURYI, THEIR USE IN TREATING CANCER AND METHOD OF SEPARATING EPIMERS THEREOF CYP4A22, UGT2B17, ECI1 TP53 4141/4885MAPT 4801/4885MAPK1 2742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.