Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.52 |
| ▸ | VPS4B | O75351 | 1/20 | 0.52 |
| ▸ | VCP | P55072 | 1/20 | 0.52 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.51 |
| ▸ | HTR1F | P30939 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR1E | P28566 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895910 | 1.00 | HTR1B (0.52) | HTR1BKMT2AMAPKAPK2VPS4BVCP | |
| SCHEMBL4899304 | 1.00 | HTR1B (0.52) | HTR1BKMT2AMAPKAPK2VPS4BVCP | |
| SCHEMBL11838932 | 0.90 | HTR1F (0.48) | HTR1BKMT2AMAPKAPK2VPS4BVCP | |
| SCHEMBL4903633 | 0.90 | SIRT1 (0.60) | HTR1BKMT2AMAPKAPK2VPS4BVCP | |
| SCHEMBL11681778 | 0.90 | SIRT1 (0.57) | KMT2AMAPKAPK2VPS4BVCPBAZ2B | |
| SCHEMBL4899779 | 0.90 | SIRT1 (0.60) | HTR1BKMT2AMAPKAPK2VPS4BVCP | |
| SCHEMBL14880207 | 0.85 | KMT2A (0.54) | HTR1BKMT2AVPS4BVCPBAZ2B | |
| SCHEMBL4897542 | 0.84 | SIRT1 (0.67) | HTR1BKMT2AMAPKAPK2BAZ2BHTR1A | |
| SCHEMBL11845531 | 0.84 | SIRT1 (0.55) | HTR1BKMT2ABAZ2BHTR1ASIRT1 | |
| SCHEMBL11844800 | 0.84 | HTR1B (0.52) | HTR1BKMT2AHTR1ASIRT1HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2008-04-03 | — | — | US | disclosed |
| US-7297704-B2 | Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives | WYETH (US) | 2007-11-20 | — | — | US | disclosed |
| US-20060205759-A1 | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives | WYETH (US) | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205759-A1 | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives | TPH1, TPH2, HTR2C | HTR1B 19/4885KMT2A 3332/4885MAPKAPK2 2878/4885 |
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | TPH1, TPH2, HTR2C | HTR1B 19/4885KMT2A 3332/4885MAPKAPK2 2878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.