SYN2 — 69 ClinVar variants
All ClinVar germline SYN2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
7 Benign · 4 Likely benign · 58 Uncertain significance
Full SYN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SYN2 p.Ala546Gly Uncertain significance Single submitter
- SYN2 p.Arg179Gln Uncertain significance Single submitter
- SYN2 p.Arg186Gln Uncertain significance Single submitter
- SYN2 p.Arg328Lys Uncertain significance Single submitter
- SYN2 p.Arg452Gln Uncertain significance Single submitter
- SYN2 p.Arg500Gln Uncertain significance Single submitter
- SYN2 p.Arg500Leu Uncertain significance Single submitter
- SYN2 p.Arg556Trp Uncertain significance Single submitter
- SYN2 p.Arg570Gln Uncertain significance Single submitter
- SYN2 p.Asp509Val Uncertain significance Single submitter
- SYN2 p.Cys360Ser Uncertain significance Single submitter
- SYN2 p.Cys390Ser Uncertain significance Single submitter
- SYN2 p.Gln532His Uncertain significance Single submitter
- SYN2 p.Glu248Lys Uncertain significance Single submitter
- SYN2 p.Gly241Arg Uncertain significance Single submitter
- SYN2 p.Gly438Arg Uncertain significance Single submitter
- SYN2 p.Gly508Arg Uncertain significance Single submitter
- SYN2 p.Gly508Glu Uncertain significance Single submitter
- SYN2 p.His274Tyr Uncertain significance Single submitter
- SYN2 p.His507Asp Uncertain significance Single submitter
- SYN2 p.Ile185Val Uncertain significance Single submitter
- SYN2 p.Ile235Val Uncertain significance Single submitter
- SYN2 p.Leu297Val Uncertain significance Single submitter
-
SYN2 p.Pro107Ser
Uncertain significance
Single submitter
schizophrenia
- SYN2 p.Pro426Leu Uncertain significance Single submitter
- SYN2 p.Pro455Thr Uncertain significance Single submitter
- SYN2 p.Pro501Leu Uncertain significance Single submitter
- SYN2 p.Ser445Leu Uncertain significance Single submitter
- SYN2 p.Thr303Ile Uncertain significance Single submitter
- SYN2 p.Thr421Ile Uncertain significance Single submitter
- SYN2 p.Val183Met Uncertain significance Single submitter
- SYN2 p.Val266Gly Uncertain significance Single submitter
- SYN2 p.Val400Leu Uncertain significance Single submitter
- SYN2 p.Val400Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- SYN2 p.Arg315Trp Uncertain significance Single submitter
- SYN2 p.Arg500Trp Uncertain significance Single submitter
- SYN2 p.Asn284Ser Uncertain significance Single submitter
- SYN2 p.Cys390Tyr Uncertain significance Single submitter
- SYN2 p.Glu561Gly Uncertain significance Single submitter
- SYN2 p.Glu563Lys Uncertain significance Single submitter
- SYN2 p.Gly366Ser Uncertain significance Single submitter
- SYN2 p.His376Tyr Uncertain significance Single submitter
- SYN2 p.Leu210Phe Uncertain significance Single submitter
- SYN2 p.Met277Val Uncertain significance Single submitter
- SYN2 p.Met349Ile Uncertain significance Single submitter
- SYN2 p.Met349Val Uncertain significance Single submitter
- SYN2 p.Phe547Val Uncertain significance Single submitter
- SYN2 p.Ser557Cys Uncertain significance Single submitter
All SYN2 variants
Benign 7
- p.Ala54Val Multiple submitters
- p.Thr506Ala Multiple submitters
- p.Pro74_Thr75insGlnProAlaPro Single submitter
- p.Ala193Val No assertion criteria SYN2-related disorder
- p.Ala566= No assertion criteria SYN2-related disorder
- p.Lys128Arg No assertion criteria SYN2-related disorder
- p.Ser540= No assertion criteria SYN2-related disorder
Likely benign 4
- p.Arg176= Single submitter
- p.Pro74_Thr75insGlnProAlaProGlnProAlaPro Single submitter
- c.1370-4del No assertion criteria SYN2-related disorder
- p.Thr263= No assertion criteria SYN2-related disorder
Uncertain significance 58
- c.1369+21G>C Single submitter
- p.Ala302Gly Single submitter
- p.Ala546Gly Single submitter ⚠
- p.Arg179Gln Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg315Trp Single submitter ⚠
- p.Arg328Lys Single submitter ⚠
- p.Arg452Gln Single submitter ⚠
- p.Arg500Gln Single submitter ⚠
- p.Arg500Leu Single submitter ⚠
- p.Arg500Trp Single submitter ⚠
- p.Arg556Trp Single submitter ⚠
- p.Arg570Gln Single submitter ⚠
- p.Asn284Ser Single submitter ⚠
- p.Asp509Val Single submitter ⚠
- p.Cys223Ser Single submitter
- p.Cys360Ser Single submitter ⚠
- p.Cys390Ser Single submitter ⚠
- p.Cys390Tyr Single submitter ⚠
- p.Gln529Ter Single submitter schizophrenia
- p.Gln532His Single submitter ⚠
- p.Glu248Gly Single submitter
- p.Glu248Lys Single submitter ⚠
- p.Glu408Ter Single submitter
- p.Glu561Gly Single submitter ⚠
- p.Glu563Lys Single submitter ⚠
- p.Gly241Arg Single submitter ⚠
- p.Gly366Ser Single submitter ⚠
- p.Gly438Arg Single submitter ⚠
- p.Gly508Arg Single submitter ⚠
- p.Gly508Glu Single submitter ⚠
- p.His274Tyr Single submitter ⚠
- p.His376Tyr Single submitter ⚠
- p.His507Asp Single submitter ⚠
- p.Ile185Val Single submitter ⚠
- p.Ile203Thr Single submitter
- p.Ile235Val Single submitter ⚠
- p.Leu210Phe Single submitter ⚠
- p.Leu297Val Single submitter ⚠
- p.Leu524fs Single submitter
- p.Met277Val Single submitter ⚠
- p.Met349Ile Single submitter ⚠
- p.Met349Val Single submitter ⚠
- p.Phe547Val Single submitter ⚠
- p.Pro107Ser Single submitter schizophrenia ⚠
- p.Pro426Leu Single submitter ⚠
- p.Pro455Thr Single submitter ⚠
- p.Pro501Leu Single submitter ⚠
- p.Ser445Leu Single submitter ⚠
- p.Ser557Cys Single submitter ⚠
- p.Thr303Ile Single submitter ⚠
- p.Thr339Ser Single submitter
- p.Thr421Ile Single submitter ⚠
- p.Val183Met Single submitter ⚠
- p.Val266Gly Single submitter ⚠
- p.Val400Leu Single submitter ⚠
- p.Val400Met Single submitter ⚠
- c.1308+1G>A No assertion criteria SYN2-related disorder