Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.53 |
| ▸ | PGR | P06401 | 4/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 7/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | SERPINA6 | P08185 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.52 |
| ▸ | SNCA | P37840 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | AR | P10275 | 3/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.52 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17209908 | 0.86 | SHBG (0.76) | SHBGALDH1A1NR3C1PGRADRA1A | |
| SCHEMBL1249378 | 0.83 | SHBG (0.53) | SHBGALDH1A1NR3C1PGRADRA1A | |
| SCHEMBL26669368 | 0.83 | SHBG (0.53) | SHBGALDH1A1NR3C1PGRADRA1A | |
| SCHEMBL17209919 | 0.82 | CYP19A1 (0.76) | SHBGALDH1A1NR3C1PGRLMNA | |
| SCHEMBL13084093 | 0.82 | CYP19A1 (0.76) | SHBGALDH1A1NR3C1PGRLMNA | |
| SCHEMBL21386973 | 0.80 | ALDH1A1 (0.77) | SHBGALDH1A1NR3C1PGRADRA1A | |
| SCHEMBL2838514 | 0.80 | CYP3A4 (0.55) | SHBGALDH1A1NR3C1PGRADRA1A | |
| SCHEMBL5925766 | 0.80 | CYP19A1 (0.76) | SHBGALDH1A1LMNACYP19A1HSD17B10 | |
| SCHEMBL5925769 | 0.80 | CYP19A1 (0.76) | SHBGALDH1A1LMNACYP19A1HSD17B10 | |
| SCHEMBL2832330 | 0.79 | AR (0.57) | SHBGALDH1A1NR3C1PGRADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431559-B2 | Treatment of hot flashes | PHERIN PHARMACEUTICALS, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20120108558-A1 | Treatment of Hot Flashes | PHERIN PHARMACEUTICALS, INC. | 2012-05-03 | — | — | US | disclosed |
| US-20090258040-A1 | STEROID TREATMENT FOR HOT FLASHES | PHERIN PHARMACEUTICALS, INC. (US) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258040-A1 | STEROID TREATMENT FOR HOT FLASHES | CYP19A1, SHBG, HSD17B11 | SHBG 2/4885ALDH1A1 597/4885NR3C1 25/4885 |
| US-20120108558-A1 | Treatment of Hot Flashes | HSD17B11, HSD3B1, HSD3B2 | SHBG 68/4885ALDH1A1 1117/4885NR3C1 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.