SCHEMBL10001901

SCHEMBL10001901

O=C(NO)N1CCOCC1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.57
SMN1; SMN2 Q16637 4/20 0.55
PKM P14618 1/20 0.55
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA9 Q16790 1/20 0.50
GAA P10253 2/20 0.48
MEN1 O00255 1/20 0.48
TP53 P04637 1/20 0.48
KMT2A Q03164 1/20 0.48
MMP1 P03956 1/20 0.46
MMP3 P08254 1/20 0.46
MMP8 P22894 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.45
MAPT P10636 2/20 0.44
HPGD P15428 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5800573 0.82 HTT (0.59) HTTSMN1; SMN2PKMCYP2C9CYP2C19
SCHEMBL28088453 0.81
SCHEMBL21162612 0.79 HTT (0.52) HTTSMN1; SMN2PKMCYP2C9CYP2C19
SCHEMBL675834 0.78 POLB (0.68) HTTSMN1; SMN2PKMCYP2C9CYP2C19
SCHEMBL6242198 0.78 HTT (0.55) HTTSMN1; SMN2PKMCYP2C9CYP2C19
SCHEMBL24254616 0.78 HTT (0.55) HTTSMN1; SMN2PKMCYP2C9CYP2C19
SCHEMBL17325765 0.78 HTT (0.55) HTTSMN1; SMN2PKMCYP2C9CYP2C19
SCHEMBL9459556 0.78 HTT (0.55) HTTSMN1; SMN2PKMCYP2C9CYP2C19
SCHEMBL5117284 0.78 HTT (0.55) HTTSMN1; SMN2PKMCYP2C9CYP2C19
SCHEMBL1056413 0.78 HTT (0.55) HTTSMN1; SMN2PKMCYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11608320-B2 Oxazolidinone hydroxamic acid derivatives KUWAIT UNIVERSITY (KW) 2023-03-21 US disclosed
US-20210238151-A1 OXAZOLIDINONE HYDROXAMIC ACID DERIVATIVES KUWAIT UNIVERSITY (KW) 2021-08-05 US disclosed
EP-2243628-B1 Method for making lithographic printing plates AGFA GRAPHICS NV (BE) 2012-12-05 EP disclosed
US-20120034565-A1 Lithographic printing plate precursor AGFA GRAPHICS NV (BE) 2012-02-09 US disclosed
US-20120034565-A1 Lithographic printing plate precursor AGFA GRAPHICS NV (BE) 2012-02-09 US disclosed
US-4618692-A ANTITUMOR AGENTS ASTA-WERKE AKTIENGESELLSCHAFT (DE) 1986-10-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238151-A1 OXAZOLIDINONE HYDROXAMIC ACID DERIVATIVES ALOX5, ALOX15, ALOX15B HTT 3582/4885SMN1; SMN2 4316/4885PKM 2120/4885
US-11608320-B2 Oxazolidinone hydroxamic acid derivatives ALOX5, ALOX15, ALOX15B HTT 3530/4885SMN1; SMN2 4313/4885PKM 2144/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.