Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AOC2 | O75106 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11770355 | 0.86 | NQO1 (0.47) | MAOBAPPCYP1A2CYP2C19TDP1 | |
| SCHEMBL167606 | 0.80 | DRD2 (0.56) | DRD2DRD4DRD3CYP1A2CYP2D6 | |
| SCHEMBL5248320 | 0.80 | DRD2 (0.52) | MAOBAPPDRD2DRD4DRD3 | |
| SCHEMBL5252735 | 0.78 | DRD2 (0.55) | DRD2DRD4DRD3CYP1A2CYP2D6 | |
| SCHEMBL11868582 | 0.78 | MAOB (0.50) | MAOBAPPDRD2DRD4DRD3 | |
| SCHEMBL9114592 | 0.78 | CYP1A2 (0.63) | MAOBAPPDRD2DRD4DRD3 | |
| SCHEMBL10338308 | 0.76 | MEN1 (0.60) | DRD2DRD4DRD3CYP1A2CYP2D6 | |
| SCHEMBL152253 | 0.76 | MAOB (0.48) | MAOBAPPDRD2DRD4DRD3 | |
| SCHEMBL5069758 | 0.75 | CYP1A2 (0.50) | MAOBAPPDRD2DRD4DRD3 | |
| SCHEMBL1737377 | 0.74 | LTA4H (0.52) | APPDRD2DRD4DRD3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451783-A2 | LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT | University Of Kansas (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005759-A2 | LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT | UNIVERSITY OF KANSAS (US) | 2011-01-13 | — | — | WO | disclosed |
| EP-1786424-A2 | LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT | The University of Kansas (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006023704-A2 | LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT | UNIVERSITY OF KANSAS (US) | 2006-03-02 | — | — | WO | disclosed |