SCHEMBL1000430

SCHEMBL1000430

NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1c[nH]cn1

nearest known ligand 0.45

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 3/20 0.44
▸ DPP8 Q6V1X1 1/20 0.44
▸ DPP9 Q86TI2 1/20 0.44
▸ TRHR P34981 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1000429 1.00 DPP4 (0.44) DPP4DPP8DPP9TRHR
SCHEMBL2182026 1.00 DPP4 (0.44) DPP4DPP8DPP9TRHR
Bromide SCHEMBL7325613 0.99 DPP4 (0.43) DPP4DPP8DPP9TRHR
Bromide SCHEMBL5735593 0.99 DPP4 (0.43) DPP4DPP8DPP9TRHR
Bromide SCHEMBL7325997 0.99 DPP4 (0.43) DPP4DPP8DPP9TRHR
SCHEMBL10454953 0.96 TRHR (0.43) DPP4DPP8DPP9TRHR
SCHEMBL10454951 0.96 TRHR (0.43) DPP4DPP8DPP9TRHR
SCHEMBL5734357 0.91 DPP4 (0.44) DPP4DPP8DPP9
SCHEMBL4595209 0.91 DPP4 (0.44) DPP4DPP8DPP9
SCHEMBL4595206 0.91 DPP4 (0.44) DPP4DPP8DPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0382842-B1 NOOTROPIC Grünenthal GmbH (DE) 1993-09-22 — — EP claimed
US-5118670-A PROCESS AND COMPOSITION FOR INCREASING BRAIN DOPAMINE RELEASE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1992-06-02 — — US claimed
EP-0382842-A1 NOOTROPIC Grünenthal GmbH (DE) 1990-08-22 — — EP claimed
EP-0373904-A1 Process and composition for increasing brain dopamine release MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1990-06-20 — — EP claimed
EP-0194443-B1 NOVEL PEPTIDES, COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PRODUCTION TANABE SEIYAKU CO., LTD. (JP) 1989-08-30 — — EP claimed
EP-0194443-A2 Novel peptides, compositions containing them and processes for their production TANABE SEIYAKU CO., LTD. (JP) 1986-09-17 — — EP claimed
EP-0168042-A2 Dihydroorotic acid derivatives, processes for their preparing and pharmaceutical composition containing them TANABE SEIYAKU CO., LTD. (JP) 1986-01-15 — — EP claimed
US-4045556-A ANTIDEPRESSANTS, PYSCHOSTIMULANTS; SILYLATION SCHWERTNER EBERHARD 1977-08-30 — — US claimed
JP-7082166-A — — None — — JP disclosed
JP-63316724-A — — None — — JP disclosed
JP-62022797-A — — None — — JP disclosed
JP-1025728-A — — None — — JP disclosed
JP-4273898-A — — None — — JP disclosed
US-20260091083-A1 CYCLIC PROSAPOSIN PEPTIDES AND USES THEREOF CHILDREN'S MEDICAL CENTER CORPORATION (US) 2026-04-02 — — US disclosed
EP-0168042-A2 Dihydroorotic acid derivatives, processes for their preparing and pharmaceutical composition containing them TANABE SEIYAKU CO., LTD. (JP) 1986-01-15 — — EP disclosed
US-4564609-A NERVOUS SYSTEM DISORDERS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1986-01-14 — — US disclosed
US-4563306-A CONSCIOUSNESS DISORDERS TANABE SEIYAKU CO., LTD. (JP) 1986-01-07 — — US disclosed
EP-0134582-A2 Novel peptides and process for preparing the same and pharmaceutical composition Tanabe Seiyaku Co., Ltd. (JP) 1985-03-20 — — EP disclosed
EP-0123444-A1 4-Substituted-2-azetidinone compound, process of producing the compounds, and medicaments containing the compounds YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1984-10-31 — — EP disclosed
US-4045556-A ANTIDEPRESSANTS, PYSCHOSTIMULANTS; SILYLATION SCHWERTNER EBERHARD 1977-08-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260091083-A1 CYCLIC PROSAPOSIN PEPTIDES AND USES THEREOF PSAP, VIP, IAPP DPP4 1147/4885DPP8 1688/4885DPP9 1555/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback