Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10007255 | 0.91 | POLB (0.43) | MEN1KMT2APOLBSMN1; SMN2TDP1 | |
| SCHEMBL10008779 | 0.91 | MAPK8 (0.46) | MEN1KMT2APOLBSMN1; SMN2MAPT | |
| SCHEMBL10008932 | 0.89 | L3MBTL1 (0.41) | MEN1KMT2APOLBSMN1; SMN2TDP1 | |
| SCHEMBL10008536 | 0.85 | L3MBTL1 (0.45) | KMT2APOLBKCNQ2MAPTMAPK8 | |
| SCHEMBL10008637 | 0.85 | L3MBTL1 (0.47) | MEN1KMT2APOLBSMN1; SMN2TRPV1 | |
| SCHEMBL10008143 | 0.84 | MAPK8 (0.48) | MEN1KMT2APOLBSMN1; SMN2TDP1 | |
| SCHEMBL10008582 | 0.81 | SMN1; SMN2 (0.48) | MEN1KMT2APOLBSMN1; SMN2TRPV1 | |
| SCHEMBL10008612 | 0.80 | MAPK8 (0.50) | MEN1KMT2APOLBMAPTMAPK8 | |
| SCHEMBL1492252 | 0.80 | MAPK8 (0.50) | MEN1KMT2APOLBSMN1; SMN2TDP1 | |
| SCHEMBL10008769 | 0.80 | EGFR (0.44) | MEN1KMT2APOLBMAPTMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172333-A1 | PYRROLO-PYRIDINE DERIVATIVES AS ACTIVATORS OF AMPK | GLAXOSMITHKLINE LLC (US) | 2012-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172333-A1 | PYRROLO-PYRIDINE DERIVATIVES AS ACTIVATORS OF AMPK | PRKAB1, PRKAG1, PRKAB2 | MEN1 4029/4885KMT2A 2761/4885POLB 1329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.