Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | CDK1 | P06493 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.58 |
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | AKT1 | P31749 | 1/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5642702 | 0.83 | MEN1 (0.71) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL3755191 | 0.81 | MEN1 (0.67) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL2950147 | 0.81 | MEN1 (0.67) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL2413088 | 0.80 | ROCK2 (0.68) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL5002947 | 0.80 | ALDH1A1 (0.68) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL8191196 | 0.80 | MEN1 (0.66) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL5002951 | 0.80 | ALDH1A1 (0.68) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL10323215 | 0.80 | MEN1 (0.66) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL10324474 | 0.80 | MEN1 (0.66) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL10323266 | 0.77 | MEN1 (0.63) | CYP1A2CYP2C9CYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142750-A1 | INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2012-06-07 | — | — | US | disclosed |
| US-20120142750-A1 | INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2012-06-07 | — | — | US | disclosed |
| US-20090176870-A1 | TGF-BETA MODULATORS AND METHODS FOR USING THE SAME | MARSHFIELD CLINIC (US) | 2009-07-09 | — | — | US | disclosed |
| US-20090155311-A1 | INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS | MED. COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. (US) | 2009-06-18 | — | — | US | disclosed |
| US-20090155311-A1 | INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS | MED. COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. (US) | 2009-06-18 | — | — | US | disclosed |
| WO-2007081878-A2 | INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. (US) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090155311-A1 | INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS | IDO2, IDO1, INMT | CYP1A2 210/4885CYP2C9 871/4885CYP2C19 1198/4885 |
| US-20090176870-A1 | TGF-BETA MODULATORS AND METHODS FOR USING THE SAME | TGFBR1, TGFBR2, SMAD3 | CYP1A2 2400/4885CYP2C9 2989/4885CYP2C19 3783/4885 |
| US-20120142750-A1 | INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS | IDO2, IDO1, INMT | CYP1A2 210/4885CYP2C9 871/4885CYP2C19 1198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.