Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074191 | 0.88 | ACHE (0.45) | KDM4EALDH1A1GAAHPGDNPSR1 | |
| SCHEMBL15879007 | 0.87 | ALDH1A1 (0.45) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL15879541 | 0.86 | PKM (0.47) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL3396649 | 0.84 | KDM4E (0.41) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL3993627 | 0.83 | ACHE (0.43) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL2335965 | 0.83 | KDM4E (0.39) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| Water SCHEMBL4610904 | 0.82 | ACHE (0.43) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL382590 | 0.81 | KDM4E (0.48) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL1836203 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL11063962 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2607431-B1 | Cyanine dye compounds | LIFE TECHNOLOGIES CORP (US) | 2016-08-24 | — | — | EP | disclosed |
| US-9382425-B2 | Aza-benzazolium containing cyanine dyes | Life Technologies Corporation (US) | 2016-07-05 | — | — | US | disclosed |
| US-9150922-B2 | Cyanine compounds and their application as quenching compounds | Life Technologies Corporation (US) | 2015-10-06 | — | — | US | disclosed |
| US-9057929-B2 | Quinolinium single crystals for use in nonlinear optics | AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2015-06-16 | — | — | US | disclosed |
| US-20150031579-A1 | Aza-Benzazolium Containing Cyanine Dyes | MOLECULAR PROBES, INC. | 2015-01-29 | — | — | US | disclosed |
| US-8883415-B2 | Aza-benzazolium containing cyanine dyes | Life Technologies Corporation (US) | 2014-11-11 | — | — | US | disclosed |
| US-20140295437-A1 | Cyanine compounds and their application as quenching compounds | Life Technologies Corporation (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140204457-A1 | QUINOLINIUM SINGLE CRYSTALS FOR USE IN NONLINEAR OPTICS | AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2014-07-24 | — | — | US | disclosed |
| EP-1720944-B1 | CYANINE DYE COMPOUNDS | LIFE TECHNOLOGIES CORP (US) | 2013-07-17 | — | — | EP | disclosed |
| US-20130178395-A1 | Aza-Benzazolium Containing Cyanine Dyes | Life Technologies Corporation (US) | 2013-07-11 | — | — | US | disclosed |
| US-5578251-A | NONLINEAR-OPTICAL RESPONSE; ALKYLATION | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| US-5360582-A | Compositions with polymers for light sensitive elements | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-11-01 | — | — | US | disclosed |
| EP-0594697-A1 | NONLINEAR OPTICAL MATERIALS CONTAINING POLAR DISULFONE-FUNCTIONALIZED MOLECULES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0332044-B1 | HETEROCYCLIC COMPOUNDS CONTAINING 4,6-BIS-TRICHLOROMETHYL-S-TRIAZIN-2-YL GROUPS, PROCESS FOR THEIR PREPARATION AND PHOTOSENSITIVE MIXTURE CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-16 | — | — | EP | disclosed |
| WO-1993002383-A1 | NONLINEAR OPTICAL MATERIALS CONTAINING POLAR DISULFONE-FUNCTIONALIZED MOLECULES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1993-02-04 | — | — | WO | disclosed |
| US-5055579-A | Photoinitiators; high sensitivity in visible spectral range; stability | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |
| US-4966828-A | PHOTOINITIATORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-10-30 | — | — | US | disclosed |
| EP-0332044-A1 | Heterocyclic compounds containing 4,6-bis-trichloromethyl-s-triazin-2-yl groups, process for their preparation and photosensitive mixture containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-09-13 | — | — | EP | disclosed |
| EP-0135863-A2 | Carbonylmethyleneheterocycles containing trihalogenmethyl-groups, process for their preparation and light-sensitive mixtures containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-04-03 | — | — | EP | disclosed |
| US-3944556-A | PHOTOCONDUCTOR, FLUORESCENT, PHOTOGRAPHY | FUJI PHOTO FILM CO., LTD. (JA) | 1976-03-16 | — | — | US | disclosed |