Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | LIPA | P38571 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.32 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15014108 | 1.00 | NR1H2 (0.37) | NR1H2KMT2AALDH1A1CYP19A1LIPA | |
| SCHEMBL1001604 | 1.00 | NR1H2 (0.37) | NR1H2KMT2AALDH1A1CYP19A1LIPA | |
| SCHEMBL1932287 | 0.92 | NR1H2 (0.41) | NR1H2KMT2AALDH1A1LIPACTSS | |
| SCHEMBL13181112 | 0.87 | ALDH1A1 (0.48) | NR1H2KMT2AALDH1A1LIPACTSS | |
| SCHEMBL24571070 | 0.85 | NR1H2 (0.40) | NR1H2KMT2AALDH1A1CYP19A1LIPA | |
| SCHEMBL5792781 | 0.85 | NR1H2 (0.47) | NR1H2KMT2AALDH1A1LIPACTSS | |
| SCHEMBL13152774 | 0.85 | THRA (0.44) | NR1H2KMT2AALDH1A1LIPACTSS | |
| SCHEMBL23223892 | 0.85 | NR1H2 (0.40) | NR1H2KMT2AALDH1A1CYP19A1LIPA | |
| SCHEMBL5792776 | 0.85 | NR1H2 (0.47) | NR1H2KMT2AALDH1A1LIPACTSS | |
| SCHEMBL8714823 | 0.85 | CHRM2 (0.40) | NR1H2KMT2AALDH1A1LIPACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875327-B2 | nematic phase consisting of a lactone ring of pyranone, a cyclohexylene or 1,4-phenylene ring, or replaced by one or more fluorine; controlling temperature, optical and dielectric anisotropy, photostability, heat resistance | CHISSO CORPORATION (JP) | 2011-01-25 | — | — | US | disclosed |
| US-20100038588-A1 | Liquid Crystal Compound Having Lactone Ring, Liquid Crystal Composition, And Liquid Crystal Display Device | CHISSO CORPORATION (JP) | 2010-02-18 | — | — | US | disclosed |
| US-7618688-B2 | Liquid crystal compound having lactone ring, liquid crystal composition, and liquid crystal display device | CHISSO CORPORATION (JP) | 2009-11-17 | — | — | US | disclosed |
| EP-1785467-B1 | Liquid crystal compound having lactone ring, liquid crystal composition, and liquid crystal display device | CHISSO CORP (JP) | 2009-03-18 | — | — | EP | disclosed |
| US-20070108410-A1 | Liquid crystal compound having lactone ring, liquid crystal composition, and liquid crystal display device | CHISSO CORPORATION | 2007-05-17 | — | — | US | disclosed |
| EP-1785467-A1 | Liquid crystal compound having lactone ring, liquid crystal composition, and liquid crystal display device | CHISSO CORPORATION (JP) | 2007-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100038588-A1 | Liquid Crystal Compound Having Lactone Ring, Liquid Crystal Composition, And Liquid Crystal Display Device | TCF7L2, TCF7, CA7 | NR1H2 67/4885KMT2A 2903/4885ALDH1A1 570/4885 |
| US-20070108410-A1 | Liquid crystal compound having lactone ring, liquid crystal composition, and liquid crystal display device | TCF7L2, TCF7, CA7 | NR1H2 69/4885KMT2A 2876/4885ALDH1A1 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.