Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 1/20 | 0.60 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18430437 | 0.80 | ALDH1A1 (0.50) | PLA2G1BATG4BALDH1A1RXFP1MEN1 | |
| SCHEMBL23531571 | 0.77 | ALDH1A1 (0.48) | PLA2G1BATG4BALDH1A1RXFP1MEN1 | |
| SCHEMBL623505 | 0.77 | ALDH1A1 (0.48) | PLA2G1BATG4BALDH1A1RXFP1MEN1 | |
| SCHEMBL623740 | 0.77 | ADORA2A (0.71) | ALDH1A1RXFP1MEN1KMT2AADORA2A | |
| SCHEMBL14624610 | 0.76 | PLA2G1B (0.43) | PLA2G1BATG4BALDH1A1RXFP1ADORA2A | |
| SCHEMBL10017671 | 0.74 | GAA (0.48) | PLA2G1BATG4BALDH1A1RXFP1MEN1 | |
| SCHEMBL3139516 | 0.74 | L3MBTL1 (0.49) | PLA2G1BATG4BALDH1A1RXFP1MEN1 | |
| SCHEMBL2809243 | 0.70 | MAPT (0.56) | ALDH1A1RXFP1MEN1KMT2ATSHR | |
| SCHEMBL3050182 | 0.70 | ADORA2A (0.55) | ALDH1A1RXFP1MEN1KMT2AADORA2A | |
| SCHEMBL2644096 | 0.70 | APOBEC3G (0.67) | ALDH1A1RXFP1MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440812-B2 | Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | NOGRA PHARMA LIMITED (IE) | 2013-05-14 | — | — | US | disclosed |
| US-8114986-B2 | Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | GIULIANI INTERNATIONAL LIMITED (IE) | 2012-02-14 | — | — | US | disclosed |
| US-20100323980-A9 | Improvements to analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | NOGRA PHARMA LIMITED (IE) | 2010-12-23 | — | — | US | disclosed |
| US-20090258837-A1 | Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | GIULIANI INTERNATIONAL LIMITED (IE) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258837-A1 | Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | TPMT, MTAP, G6PD | PLA2G1B 2850/4885ATG4B 2985/4885ALDH1A1 1888/4885 |
| US-20100323980-A9 | Improvements to analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | TPMT, G6PD, MTAP | PLA2G1B 2868/4885ATG4B 2932/4885ALDH1A1 1956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.