Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.56 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.56 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.56 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.56 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.52 |
| ▸ | TYMP | P19971 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24191242 | 1.00 | LMNA (0.64) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL10048818 | 1.00 | LMNA (0.64) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL10001659 | 1.00 | LMNA (0.64) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL14943053 | 1.00 | LMNA (0.64) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL3150082 | 1.00 | LMNA (0.64) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL20857280 | 0.91 | ALDH1A1 (0.54) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL7060133 | 0.91 | ALDH1A1 (0.54) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL9658521 | 0.91 | ALDH1A1 (0.54) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL2619734 | 0.90 | ALDH1A1 (0.51) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL13597937 | 0.90 | ALDH1A1 (0.51) | LMNAALDH1A1TP53MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114986-B2 | Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | GIULIANI INTERNATIONAL LIMITED (IE) | 2012-02-14 | — | — | US | disclosed |
| US-7884202-B2 | Nucleobases are perfluoroalkylated in a one step process with a perfluoroalkyl halide in the presence of a sulfoxide, a peroxide and an iron compound; useful as medicinal drugs, intermediates for medicinal drugs and agricultural chemicals | TOSOH CORPORATION (JP) | 2011-02-08 | — | — | US | disclosed |
| US-20100323980-A9 | Improvements to analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | NOGRA PHARMA LIMITED (IE) | 2010-12-23 | — | — | US | disclosed |
| US-7855285-B2 | Methods for selective N-9 glycosylation of purines | BRIGHAM YOUNG UNIVERSITY (US) | 2010-12-21 | — | — | US | disclosed |
| US-20090258837-A1 | Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | GIULIANI INTERNATIONAL LIMITED (IE) | 2009-10-15 | — | — | US | disclosed |
| US-20080262214-A1 | Synthesis of 2-Substituted Adenosines | CAMBRIDGE BIOTECHNOLOGY LIMITED (GB) | 2008-10-23 | — | — | US | disclosed |
| US-20080207891-A1 | Methods For Selective N-9 Glycosylation of Purines | BRIGHAM YOUNG UNIVERSITY (US) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258837-A1 | Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | TPMT, MTAP, G6PD | LMNA 4630/4885ALDH1A1 1888/4885TP53 2809/4885 |
| US-20080262214-A1 | Synthesis of 2-Substituted Adenosines | ADORA3, ADORA1, ADORA2A | LMNA 1170/4885ALDH1A1 839/4885TP53 4170/4885 |
| US-20080207891-A1 | Methods For Selective N-9 Glycosylation of Purines | PNP, SLC29A2, SLC28A2 | LMNA 2535/4885ALDH1A1 872/4885TP53 3966/4885 |
| US-20100323980-A9 | Improvements to analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation | TPMT, G6PD, MTAP | LMNA 4616/4885ALDH1A1 1956/4885TP53 3205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.