Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12767315 | 0.84 | MAPT (0.56) | MAPTKMT2AMEN1HTTTDP1 | |
| SCHEMBL12443483 | 0.83 | MAPT (0.53) | MAPTKMT2AMEN1HTTTDP1 | |
| SCHEMBL10018562 | 0.77 | MAPT (0.54) | MAPTKMT2AMEN1HTTTDP1 | |
| SCHEMBL11814353 | 0.75 | MAPT (0.57) | MAPTKMT2AMEN1HTTTDP1 | |
| SCHEMBL11814348 | 0.75 | MAPT (0.57) | MAPTKMT2AMEN1HTTTDP1 | |
| SCHEMBL13726645 | 0.75 | FNTA (0.55) | MAPTKMT2AMEN1HTTTDP1 | |
| SCHEMBL13726644 | 0.75 | FNTA (0.55) | MAPTKMT2AMEN1HTTTDP1 | |
| SCHEMBL17395842 | 0.74 | MAPT (0.65) | MAPTKMT2AMEN1HTTTDP1 | |
| SCHEMBL9313016 | 0.74 | CA12 (0.54) | MAPTKMT2AMEN1HTTTDP1 | |
| SCHEMBL17395843 | 0.74 | MAPT (0.65) | MAPTKMT2AMEN1HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178749-A1 | NS1 PROTEIN INHIBITORS | ROTH MICHAEL (US) | 2012-07-12 | — | — | US | disclosed |
| US-20120178749-A1 | NS1 PROTEIN INHIBITORS | ROTH MICHAEL (US) | 2012-07-12 | — | — | US | disclosed |
| US-8119656-B2 | Inhibitors of the influenza virus non-structural 1 protein | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-02-21 | — | — | US | disclosed |
| US-8119656-B2 | Inhibitors of the influenza virus non-structural 1 protein | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-02-21 | — | — | US | disclosed |
| US-20090170840-A1 | NS1 protein inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-07-02 | — | — | US | disclosed |
| US-20090170840-A1 | NS1 protein inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170840-A1 | NS1 protein inhibitors | MAVS, SERPINB1, SPINT2 | MAPT 2783/4885KMT2A 2284/4885MEN1 3271/4885 |
| US-20120178749-A1 | NS1 PROTEIN INHIBITORS | MAVS, SERPINB1, SPINT2 | MAPT 2783/4885KMT2A 2284/4885MEN1 3271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.