Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1002190 | 1.00 | HTR7 (0.44) | HTR7HTR6HTR1ASLC6A2SLC6A3 | |
| SCHEMBL1002277 | 0.85 | HTR7 (0.42) | HTR7HTR6HTR1ALTA4HLMNA | |
| SCHEMBL1002275 | 0.85 | HTR7 (0.42) | HTR7HTR6HTR1ALTA4HLMNA | |
| SCHEMBL996214 | 0.85 | SLC6A4 (0.42) | HTR7HTR6HTR1ASLC6A2SLC6A3 | |
| SCHEMBL996213 | 0.85 | SLC6A4 (0.42) | HTR7HTR6HTR1ASLC6A2SLC6A3 | |
| SCHEMBL994382 | 0.79 | SLC6A2 (0.45) | SLC6A2SLC6A3LTA4HMEN1LMNA | |
| SCHEMBL8645197 | 0.78 | HTR7 (0.48) | HTR7HTR6HTR1ASLC6A2SLC6A3 | |
| SCHEMBL8645200 | 0.78 | HTR7 (0.48) | HTR7HTR6HTR1ASLC6A2SLC6A3 | |
| SCHEMBL996959 | 0.76 | HTR7 (0.47) | HTR7HTR6HTR1ASLC6A2MEN1 | |
| SCHEMBL996958 | 0.76 | HTR7 (0.47) | HTR7HTR6HTR1ASLC6A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456436-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | Theravance, Inc. (US) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011011231-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-01-27 | — | — | WO | disclosed |