Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1002277 | 1.00 | HTR7 (0.42) | HTR7HTR6HTR1ATP53SIGMAR1 | |
| SCHEMBL1002192 | 0.85 | HTR7 (0.44) | HTR7HTR6HTR1ALMNALTA4H | |
| SCHEMBL1002190 | 0.85 | HTR7 (0.44) | HTR7HTR6HTR1ALMNALTA4H | |
| SCHEMBL996214 | 0.82 | SLC6A4 (0.42) | HTR7HTR6HTR1ATP53SIGMAR1 | |
| SCHEMBL996213 | 0.82 | SLC6A4 (0.42) | HTR7HTR6HTR1ATP53SIGMAR1 | |
| SCHEMBL992649 | 0.79 | HRH3 (0.40) | TP53SIGMAR1HRH3 | |
| SCHEMBL997427 | 0.78 | TP53 (0.39) | TP53SIGMAR1LMNALTA4HPTGS2 | |
| SCHEMBL997429 | 0.78 | TP53 (0.39) | TP53SIGMAR1LMNALTA4HPTGS2 | |
| SCHEMBL1079151 | 0.75 | HTR7 (0.54) | HTR7HTR6HTR1ASIGMAR1KMT2A | |
| SCHEMBL1079153 | 0.75 | HTR7 (0.54) | HTR7HTR6HTR1ASIGMAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456436-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | Theravance, Inc. (US) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011011231-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-01-27 | — | — | WO | disclosed |