Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10023013 | 0.85 | RECQL (0.35) | RECQLCA2CA1CA9 | |
| SCHEMBL17244599 | 0.82 | NPSR1 (0.34) | KDM4EMAPTKMT2AKDM5CEGLN1 | |
| SCHEMBL10023009 | 0.81 | HDAC3 (0.46) | KDM4EMAPTKMT2AKDM5CEGLN1 | |
| SCHEMBL12155314 | 0.79 | KMT2A (0.53) | KDM4EMAPTKMT2AALDH1A1RECQL | |
| SCHEMBL8423451 | 0.77 | HDAC3 (0.52) | KDM4EMAPTKMT2AALDH1A1RECQL | |
| SCHEMBL14271512 | 0.77 | — | — | |
| SCHEMBL12584010 | 0.77 | NAAA (0.39) | KDM4EMAPTKMT2AKDM5CEGLN1 | |
| SCHEMBL19061955 | 0.76 | KDM4E (0.37) | KDM4EKMT2AKDM5CEGLN1PHF8 | |
| SCHEMBL14265339 | 0.75 | KDM4E (0.39) | KDM4EMAPTKMT2AKDM5CEGLN1 | |
| SCHEMBL19068014 | 0.75 | KDM4E (0.37) | KDM4EMAPTKMT2AKDM5CEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11286231-B2 | Hydrogen-bonding compounds, compositions comprising the same, and methods of preparing and using the same | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2022-03-29 | — | — | US | disclosed |
| US-20190345096-A1 | HYDROGEN-BONDING COMPOUNDS, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME | WAKE FOREST UNIVERSITY | 2019-11-14 | — | — | US | disclosed |
| US-8828433-B2 | Hydrogel bioscaffoldings and biomedical device coatings | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2014-09-09 | — | — | US | disclosed |
| US-8324184-B2 | Anti-adhesion composites and methods of use thereof | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2012-12-04 | — | — | US | disclosed |
| US-8124757-B2 | Thiol-modified macromolecule derivatives and cross-linked materials thereof | BIOREGEN BIOMEDICAL (CHANGZHOU) CO., LTD. (CN) | 2012-02-28 | — | — | US | disclosed |
| US-20100152423-A1 | THIOL-MODIFIED MACROMOLECULE DERIVATIVES AND CROSS-LINKED MATERIALS THEREOF | BIOREGEN BIOMEDICAL (CHANGZHOU) CO., LTD. (CN) | 2010-06-17 | — | — | US | disclosed |
| US-20090124540-A1 | Anti-adhesion composites and methods of use thereof | UNIVERSITY OF UTAH | 2009-05-14 | — | — | US | disclosed |
| US-20090017091-A1 | STERILE HYALURONIC ACID POLYMER COMPOSITIONS AND RELATED METHODS | CARBYLAN THERAPEUTICS, INC. | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090017091-A1 | STERILE HYALURONIC ACID POLYMER COMPOSITIONS AND RELATED METHODS | CD44, ACR, HIRA | KDM4E 3897/4885MAPT 4430/4885KMT2A 3267/4885 |
| US-20090124540-A1 | Anti-adhesion composites and methods of use thereof | ICAM1, ITGA5, CDH1 | KDM4E 3511/4885MAPT 3572/4885KMT2A 4119/4885 |
| US-20100152423-A1 | THIOL-MODIFIED MACROMOLECULE DERIVATIVES AND CROSS-LINKED MATERIALS THEREOF | PTMS, TMT1A, EPCAM | KDM4E 2135/4885MAPT 2919/4885KMT2A 1418/4885 |
| US-11286231-B2 | Hydrogen-bonding compounds, compositions comprising the same, and methods of preparing and using the same | F12, F5, F13B | KDM4E 1625/4885MAPT 4202/4885KMT2A 3302/4885 |
| US-20190345096-A1 | HYDROGEN-BONDING COMPOUNDS, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME | F12, F5, F13B | KDM4E 1704/4885MAPT 4289/4885KMT2A 3304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.