Sugi Predict

Sugi Predict / Compounds / SCHEMBL10024704

SCHEMBL10024704

SCHEMBL10024704

CC[C@H]1O[C@@H](n2cnc(N)nc2=O)C(OC(C)=O)[C@H]1C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.52
▸ ALDH1A1 P00352 3/20 0.52
▸ DNMT1 P26358 2/20 0.52
▸ TP53 P04637 2/20 0.52
▸ GMNN O75496 1/20 0.52
▸ NFKB1 P19838 1/20 0.52
▸ THPO P40225 1/20 0.52
▸ MTOR P42345 1/20 0.52
▸ HTT P42858 1/20 0.52
▸ RAB9A P51151 1/20 0.52
▸ BLM P54132 1/20 0.52
▸ HBB P68871 1/20 0.52
▸ PMP22 Q01453 1/20 0.52
▸ ADRB1 P08588 1/20 0.42
▸ MAPT P10636 1/20 0.42
▸ TDP1 Q9NUW8 1/20 0.42
▸ HINT1 P49773 2/20 0.35
▸ THRB P10828 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ HIF1A Q16665 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14549613 1.00 LMNA (0.52) LMNAALDH1A1DNMT1TP53GMNN
SCHEMBL17366441 0.91 LMNA (0.54) LMNAALDH1A1DNMT1TP53GMNN
SCHEMBL14146164 0.89 ALDH1A1 (0.52) LMNAALDH1A1DNMT1TP53GMNN
SCHEMBL13954007 0.89 LMNA (0.58) LMNAALDH1A1DNMT1TP53GMNN
SCHEMBL10024708 0.86 ALDH1A1 (0.47) LMNAALDH1A1DNMT1TP53GMNN
SCHEMBL19506684 0.86 LMNA (0.51) LMNAALDH1A1DNMT1TP53GMNN
SCHEMBL12691013 0.84 LMNA (0.63) LMNAALDH1A1DNMT1TP53GMNN
SCHEMBL12693808 0.84 LMNA (0.63) LMNAALDH1A1DNMT1TP53GMNN
SCHEMBL13485203 0.83 DNMT1 (0.57) LMNAALDH1A1DNMT1TP53GMNN
SCHEMBL10267488 0.83 DNMT1 (0.57) LMNAALDH1A1DNMT1TP53GMNN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9416152-B2 Azacitidine process and polymorphs DR. REDDY'S LABORATORIES LTD. (IN) 2016-08-16 — — US disclosed
US-20140155588-A1 AZACITIDINE PROCESS AND POLYMORPHS DR. REDDY'S LABORATORIES INC. (US) 2014-06-05 — — US disclosed
US-8703932-B2 Azacitidine process and polymorphs DR. REDDY'S LABORATORIES LTD. (IN) 2014-04-22 — — US disclosed
US-20120029181-A1 SYNTHESIS OF 5-AZACYTIDINE PHARMION LLC (US) 2012-02-02 — — US disclosed
US-8058424-B2 Synthesis of 5-azacytidine PHARMION LLC (US) 2011-11-15 — — US disclosed
US-20110201800-A1 AZACITIDINE PROCESS AND POLYMORPHS DR. REDDY'S LABORATORIES LTD. (IN) 2011-08-18 — — US disclosed
US-20110092694-A1 SYNTHESIS OF 5-AZACYTIDINE PHARMION LLC 2011-04-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110092694-A1 SYNTHESIS OF 5-AZACYTIDINE TYMS, DNMT1, TET1 LMNA 2370/4885ALDH1A1 2154/4885DNMT1 2/4885
US-20140155588-A1 AZACITIDINE PROCESS AND POLYMORPHS AZI2, DNMT3A, DCTD LMNA 1813/4885ALDH1A1 2006/4885DNMT1 4/4885
US-20110201800-A1 AZACITIDINE PROCESS AND POLYMORPHS AZI2, DNMT3A, DCTD LMNA 1979/4885ALDH1A1 1890/4885DNMT1 4/4885
US-20120029181-A1 SYNTHESIS OF 5-AZACYTIDINE TYMS, DNMT1, TET1 LMNA 2370/4885ALDH1A1 2154/4885DNMT1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.