Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.68 |
| ▸ | CA2 | P00918 | 2/20 | 0.68 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22888675 | 0.91 | CA1 (0.55) | CA1CA2GABRA1GABRB1GABRB2 | |
| SCHEMBL9512239 | 0.89 | CA1 (0.53) | CA1CA2GABRA1GABRB1GABRB2 | |
| SCHEMBL9514348 | 0.84 | CA1 (0.47) | CA1CA2GABRA1GABRB1LMNA | |
| SCHEMBL3812448 | 0.83 | CA1 (0.74) | CA1CA2GABRA1GABRB1GABRB2 | |
| SCHEMBL10026565 | 0.83 | CA1 (0.74) | CA1CA2GABRA1GABRB1GABRB2 | |
| SCHEMBL275427 | 0.82 | CA1 (1.00) | CA1CA2GABRA1GABRB1GABRB2 | |
| SCHEMBL15445309 | 0.82 | CA1 (0.71) | CA1CA2GABRA1GABRB1GABRB2 | |
| SCHEMBL10026544 | 0.82 | CA1 (0.71) | CA1CA2GABRA1GABRB1GABRB2 | |
| SCHEMBL15176931 | 0.82 | CA1 (0.71) | CA1CA2GABRA1GABRB1GABRB2 | |
| SCHEMBL15943578 | 0.80 | CA1 (0.68) | CA1CA2GABRA1GABRB1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373605-B1 | COMPOUNDS FOR USE IN THE TREATMENT OF PAIN | UNIV DUNDEE (GB) | 2014-08-13 | — | — | EP | disclosed |
| US-8507724-B2 | Compounds for use in the treatment of pain | THE UNIVERSITY OF DUNDEE (GB) | 2013-08-13 | — | — | US | disclosed |
| US-8507724-B2 | Compounds for use in the treatment of pain | THE UNIVERSITY OF DUNDEE (GB) | 2013-08-13 | — | — | US | disclosed |
| US-20120029235-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF PAIN | THE UNIVERSITY OF DUNDEE (GB) | 2012-02-02 | — | — | US | disclosed |
| US-20120029235-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF PAIN | THE UNIVERSITY OF DUNDEE (GB) | 2012-02-02 | — | — | US | disclosed |
| WO-2010067069-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF PAIN | THE UNIVERSITY OF LIVERPOOL (GB) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029235-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF PAIN | OPRL1, OPRK1, OPRD1 | CA1 2482/4885CA2 1708/4885GABRA1 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.