Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLH | Q9Y253 | 5/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.82 |
| ▸ | POLB | P06746 | 2/20 | 0.82 |
| ▸ | APEX1 | P27695 | 2/20 | 0.82 |
| ▸ | RECQL | P46063 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.82 |
| ▸ | MMP1 | P03956 | 1/20 | 0.82 |
| ▸ | GAA | P10253 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.82 |
| ▸ | HTT | P42858 | 1/20 | 0.82 |
| ▸ | BLM | P54132 | 1/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.82 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.72 |
| ▸ | PLG | P00747 | 1/20 | 0.72 |
| ▸ | XDH | P47989 | 1/20 | 0.70 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.67 |
| ▸ | TUBB | P07437 | 1/20 | 0.67 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.67 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 3-O-Methylquercetin SCHEMBL380558 | 0.90 | POLH (1.00) | POLHKDM4EPOLBAPEX1RECQL | |
| 3-O-Methylquercetin SCHEMBL29897544 | 0.90 | POLH (1.00) | POLHKDM4EPOLBAPEX1RECQL | |
| SCHEMBL31304741 | 0.88 | POLB (0.82) | POLHKDM4EPOLBAPEX1RECQL | |
| SCHEMBL30284949 | 0.88 | POLB (0.82) | POLHKDM4EPOLBAPEX1RECQL | |
| SCHEMBL11149169 | 0.88 | POLB (0.82) | POLHKDM4EPOLBAPEX1RECQL | |
| SCHEMBL13780248 | 0.85 | POLH (0.82) | POLHKDM4EPOLBAPEX1RECQL | |
| SCHEMBL4227938 | 0.85 | POLH (0.60) | POLHKDM4EPOLBAPEX1RECQL | |
| SCHEMBL4230543 | 0.85 | POLH (0.75) | POLHKDM4EPOLBAPEX1RECQL | |
| SCHEMBL13856525 | 0.85 | MEN1 (0.78) | POLHKDM4EPOLBAPEX1RECQL | |
| SCHEMBL828941 | 0.84 | PLG (1.00) | POLHKDM4EPOLBAPEX1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170049793-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2017-02-23 | — | — | US | disclosed |
| US-20140187510-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2014-07-03 | — | — | US | disclosed |
| US-20120046242-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046242-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | POLH 2935/4885KDM4E 4001/4885POLB 2990/4885 |
| US-20140187510-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | POLH 2935/4885KDM4E 4001/4885POLB 2990/4885 |
| US-20170049793-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | POLH 2935/4885KDM4E 4001/4885POLB 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.