3-O-Methylquercetin

3-O-Methylquercetin

SCHEMBL380558

COc1c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c2c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLH Q9Y253 8/20 1.00
KDM4E B2RXH2 3/20 1.00
POLB P06746 3/20 1.00
APEX1 P27695 3/20 1.00
RECQL P46063 3/20 1.00
MEN1 O00255 2/20 1.00
MMP1 P03956 2/20 1.00
GAA P10253 2/20 1.00
MAPT P10636 2/20 1.00
BLM P54132 2/20 1.00
KMT2A Q03164 2/20 1.00
HSD17B10 Q99714 2/20 1.00
HTT P42858 1/20 1.00
NOX4 Q9NPH5 2/20 0.84
PLG P00747 1/20 0.84
TUBB4A P04350 1/20 0.82
TUBB P07437 1/20 0.82
TUBA3C P0DPH7 1/20 0.82
TUBA1B P68363 1/20 0.82
TUBA4A P68366 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
3-O-Methylquercetin SCHEMBL29897544 1.00 POLH (1.00) POLHKDM4EPOLBAPEX1RECQL
SCHEMBL828941 0.91 PLG (1.00) POLHKDM4EPOLBAPEX1RECQL
SCHEMBL29825010 0.91 PLG (1.00) POLHKDM4EPOLBAPEX1RECQL
SCHEMBL30266565 0.90 TUBB4A (1.00) POLHKDM4EPOLBAPEX1RECQL
SCHEMBL17102291 0.90 POLH (0.82) POLHKDM4EPOLBAPEX1RECQL
SCHEMBL15676566 0.90 TUBB4A (1.00) POLHKDM4EPOLBAPEX1RECQL
SCHEMBL1250534 0.90 TUBB4A (1.00) POLHKDM4EPOLBAPEX1RECQL
SCHEMBL13780248 0.90 POLH (0.82) POLHKDM4EPOLBAPEX1RECQL
SCHEMBL31230209 0.90 TUBB4A (1.00) POLHKDM4EPOLBAPEX1RECQL
SCHEMBL10026580 0.90 POLH (0.82) POLHKDM4EPOLBAPEX1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 511 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12514278-B2 Tobacco-derived composition R.J. REYNOLDS TOBACCO COMPANY (US) 2026-01-06 US claimed
US-20250319058-A1 COMPOSITIONS AND METHODS USING A COMBINATION OF FISETIN AND QUERCETIN FOR CELLULAR ENERGY NESTLE SA (CH) 2025-10-16 US claimed
US-20250312307-A1 COMPOSITIONS AND METHODS USING A COMBINATION OF FISETIN AND QUERCETIN FOR USE IN CARTILAGE DEGENERATION NESTLE SA (CH) 2025-10-09 US claimed
CN-118511948-B Vacuum freeze-dried feed for climbing pets and preparation method thereof 青岛大任富城畜牧有限公司 2025-04-08 CN claimed
CN-119095594-A Compositions and methods for cartilage degradation using a combination of fisetin and quercetin 雀巢产品有限公司 2024-12-06 CN claimed
CN-119072309-A Compositions and methods for using a combination of neisseria and quercetin for cellular energy 雀巢产品有限公司 2024-12-03 CN claimed
CN-118680921-A Hypoglycemic compound and application thereof 广东省科学院广州地理研究所 2024-09-24 CN claimed
CN-118615276-A Compound for inhibiting alpha-glucosidase and application thereof 广东省科学院广州地理研究所 2024-09-10 CN claimed
CN-118511948-A Vacuum freeze-dried feed for climbing pets and preparation method thereof 青岛大任富城畜牧有限公司 2024-08-20 CN claimed
CN-118304334-A Preparation and application of traditional Chinese medicine fructus rhodomyrti liver protection active ingredient 北京工业大学 2024-07-09 CN claimed
US-20050042311-A1 Use of an opuntia ficus-indica extract and compounds isolated therefrom for protecting nerve cells AGRICULTURAL CORPORATIVE SE.JONG CO. (KR) 2005-02-24 US claimed
EP-1448188-A1 USE OF AN OPUNTIA FICUS-INDICA EXTRACT AND COMPOUNDS ISOLATED THEREFROM FOR PROTECTING NERVE CELLS Korea Institute of Science and Technology (KR) 2004-08-25 EP claimed
US-20040162247-A1 Therapeutic agent or osteoporosis comprising an active ingredient of quercetin derivatives KIM CHUNG-SOOK (KR) 2004-08-19 US claimed
WO-2004052351-A1 NOVEL USE OF LYCOPENE DSM IP ASSETS B.V. (CH) 2004-06-24 WO claimed
CN-1442146-A New pharmaceutical of cactus total flavone and its preparation method SHENYANG UNIV OF MEDICINE (CN) 2003-09-17 CN claimed
EP-1309326-A1 A THERAPEUTIC AGENT OF OSTEOPOROSIS COMPRISING AN ACTIVE INGREDIENT OF QUERCETIN DERIVATIVES Korea Institute of Oriental Medicine (KR) 2003-05-14 EP claimed
WO-2003037324-A1 USE OF AN OPUNTIA FICUS-INDICA EXTRACT AND COMPOUNDS ISOLATED THEREFROM FOR PROTECTING NERVE CELLS KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-05-08 WO claimed
US-20020165169-A1 Therapeutic agent of osteoporosis comprising an active ingredient of quercetin derivatives KOREA INSTITUTE OF ORIENTAL MEDICINE (KR) 2002-11-07 US claimed
WO-2002017909-A1 A THERAPEUTIC AGENT OF OSTEOPOROSIS COMPRISING AN ACTIVE INGREDIENT OF QUERCETIN DERIVATIVES KOREA INSTITUTE OF ORIENTAL MEDICINE (KR) 2002-03-07 WO claimed
WO-2001003687-A2 METHOD AND COMPOSITIONS FOR INHIBITING BIOSYNTHESIS OR BIOACTIVITY OF ENDOGENOUS STEROID SEX HORMONES IN HUMANS CEDARS-SINAI MEDICAL CENTER (US) 2001-01-18 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040162247-A1 Therapeutic agent or osteoporosis comprising an active ingredient of quercetin derivatives NFATC1, MKI67, SOST POLH 3604/4885KDM4E 952/4885POLB 3516/4885
US-20020165169-A1 Therapeutic agent of osteoporosis comprising an active ingredient of quercetin derivatives NFATC1, MKI67, SOST POLH 3627/4885KDM4E 893/4885POLB 3525/4885
US-20050042311-A1 Use of an opuntia ficus-indica extract and compounds isolated therefrom for protecting nerve cells ACHE, CHAT, NOTUM POLH 3904/4885KDM4E 4050/4885POLB 2822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.