Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.60 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14667436 | 0.85 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL28311857 | 0.83 | KDM4E (0.58) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL28223719 | 0.80 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL29273188 | 0.79 | KDM4E (0.63) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL10028052 | 0.79 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL28312055 | 0.79 | KDM4E (0.54) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL28879156 | 0.77 | NPC1 (0.57) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL6827363 | 0.76 | KDM4E (0.58) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL12826605 | 0.75 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDTDP1MAPT | |
| SCHEMBL2551317 | 0.75 | KDM4E (0.66) | ALDH1A1KDM4EHPGDHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010259-A1 | Methods of Treating an Overweight or Obese Subject | ZAFGEN, INC. | 2012-01-12 | — | — | US | disclosed |
| EP-1905762-A1 | PYRAZOLONE DERIVATIVE | Genecare Research Institute Co., Ltd (JP) | 2008-04-02 | — | — | EP | disclosed |
| EP-1900728-A1 | PHARMACEUTICAL COMPOSITION COMPRISING PYRAZOLONE DERIVATIVE | Genecare Research Institute Co., Ltd (JP) | 2008-03-19 | — | — | EP | disclosed |
| US-7173033-B2 | Nitrogen-containing heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2007-02-06 | — | — | US | disclosed |
| US-7173033-B2 | Nitrogen-containing heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2007-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010259-A1 | Methods of Treating an Overweight or Obese Subject | METAP2, METAP1, ACER2 | ALDH1A1 802/4885KDM4E 905/4885HPGD 2251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.