Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10028056 | 0.79 | ALDH1A1 (0.60) | ALDH1A1KDM4ESMN1; SMN2MAPTHPGD | |
| SCHEMBL3634969 | 0.76 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1SCN9AKDM4EEP300 | |
| SCHEMBL7701143 | 0.75 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1HSD11B1SCN9AKDM4E | |
| SCHEMBL3875107 | 0.75 | ALDH1A1 (0.77) | ALDH1A1L3MBTL1KDM4EMAPTHPGD | |
| SCHEMBL29941707 | 0.75 | ALDH1A1 (0.77) | ALDH1A1L3MBTL1KDM4EMAPTHPGD | |
| SCHEMBL19626088 | 0.75 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1HSD11B1SCN9AKDM4E | |
| SCHEMBL28223719 | 0.75 | ALDH1A1 (0.61) | ALDH1A1KDM4ESMN1; SMN2MAPTHPGD | |
| SCHEMBL17810834 | 0.74 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1HSD11B1SCN9AEP300 | |
| SCHEMBL22931244 | 0.74 | ALDH1A1 (0.67) | ALDH1A1L3MBTL1SCN9AKDM4ESMN1; SMN2 | |
| SCHEMBL10028048 | 0.74 | SMN1; SMN2 (0.51) | ALDH1A1HSD11B1KDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010259-A1 | Methods of Treating an Overweight or Obese Subject | ZAFGEN, INC. | 2012-01-12 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010259-A1 | Methods of Treating an Overweight or Obese Subject | METAP2, METAP1, ACER2 | ALDH1A1 802/4885L3MBTL1 3133/4885HSD11B1 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.