Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 2/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8523655 | 0.86 | KEAP1 (0.44) | KEAP1NFE2L2PTK2PTGS1L3MBTL1 | |
| SCHEMBL4624724 | 0.74 | KEAP1 (0.47) | KEAP1NFE2L2PTGS1L3MBTL1NR3C1 | |
| SCHEMBL22000403 | 0.71 | LIPG (0.47) | KEAP1NFE2L2PTGS1L3MBTL1ALDH1A1 | |
| SCHEMBL4866296 | 0.71 | KEAP1 (0.50) | KEAP1NFE2L2PTK2PTGS1L3MBTL1 | |
| SCHEMBL8504969 | 0.71 | ALDH1A1 (0.45) | KEAP1PTGS1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL8867618 | 0.70 | KEAP1 (0.46) | KEAP1NFE2L2PTGS1L3MBTL1NR3C1 | |
| Hydrochloric Acid SCHEMBL15225007 | 0.69 | KEAP1 (0.49) | KEAP1NFE2L2PTK2PTGS1L3MBTL1 | |
| SCHEMBL8867626 | 0.69 | PIK3CG (0.49) | KEAP1NFE2L2PTGS1L3MBTL1NR3C1 | |
| SCHEMBL16323291 | 0.69 | KEAP1 (0.45) | KEAP1NFE2L2PTGS1L3MBTL1NR3C1 | |
| SCHEMBL3382924 | 0.68 | ALDH1A1 (0.37) | ALDH1A1KDM4ERCE1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875619-B2 | N-[4-(4-{2-[bis-((2S,3R)-2,3,4-trihydroxybutyl)amino]ethylamino}phenyl)butyl]-N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidine trihydrochloride; treating chronic bronchitis, cystic fibrosis, ventilator-induced pneumonia, asthma, chronic obstructive pulmonary disease, pneumonia and emphysema | PARION SCIENCES, INC. (US) | 2011-01-25 | — | — | US | disclosed |
| US-7820678-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| EP-1599096-B1 | HETERO SUBSTITUED SODIUM CHANNEL BLOCKERS | PARION SCIENCES INC (US) | 2008-12-24 | — | — | EP | disclosed |
| US-20080076782-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2008-03-27 | — | — | US | disclosed |
| US-7345044-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-20060142581-A1 | Hetero substitued sodium channel blockers | PARION SCIENCES, INC. (US) | 2006-06-29 | — | — | US | disclosed |
| US-7030117-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2006-04-18 | — | — | US | disclosed |
| US-7026325-B2 | Sodium channel blockers | PARION-SCIENCES, INC. (US) | 2006-04-11 | — | — | US | disclosed |
| US-20060063780-A1 | Sodium channel blockers | JOHNSON MICHAEL R | 2006-03-23 | — | — | US | disclosed |
| US-6995160-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2006-02-07 | — | — | US | disclosed |
| US-6903105-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2005-06-07 | — | — | US | disclosed |
| US-20050113389-A1 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2005-05-26 | — | — | US | disclosed |
| US-20050113388-A1 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2005-05-26 | — | — | US | disclosed |
| US-20050113390-A1 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2005-05-26 | — | — | US | disclosed |
| US-20040162296-A1 | Sodium channel blockers | PARION SCIENCES, INC. | 2004-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142581-A1 | Hetero substitued sodium channel blockers | SCN2B, CACNA1B, CACNA1G | KEAP1 3183/4885NFE2L2 2469/4885PTK2 4090/4885 |
| US-20050113390-A1 | Sodium channel blockers | HCN4, SCN2B, SCN5A | KEAP1 1076/4885NFE2L2 3712/4885PTK2 4374/4885 |
| US-20050113389-A1 | Sodium channel blockers | HCN4, SCN2B, SCN5A | KEAP1 1076/4885NFE2L2 3712/4885PTK2 4374/4885 |
| US-20080076782-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | KEAP1 1076/4885NFE2L2 3712/4885PTK2 4374/4885 |
| US-20050113388-A1 | Sodium channel blockers | HCN4, SCN2B, SCN5A | KEAP1 1076/4885NFE2L2 3712/4885PTK2 4374/4885 |
| US-20040162296-A1 | Sodium channel blockers | HCN4, SCN2B, SCN5A | KEAP1 1076/4885NFE2L2 3712/4885PTK2 4374/4885 |
| US-20060063780-A1 | Sodium channel blockers | HCN4, SCN2B, SCN5A | KEAP1 1076/4885NFE2L2 3712/4885PTK2 4374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.