SCHEMBL1002849

SCHEMBL1002849

O=C(c1ccccc1)N1CCC(F)C1=O

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.57
SMN1; SMN2 Q16637 1/20 0.52
ACHE P22303 1/20 0.46
HPGD P15428 2/20 0.45
GAA P10253 1/20 0.44
CYP1A2 P05177 1/20 0.44
MAPT P10636 1/20 0.44
CYP2C19 P33261 1/20 0.44
KMT2A Q03164 1/20 0.44
EPHX1 P07099 1/20 0.43
L3MBTL3 Q96JM7 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
NPC1 O15118 1/20 0.43
PPARG P37231 1/20 0.43
HTT P42858 1/20 0.43
RAB9A P51151 1/20 0.43
NCOA2 Q15596 1/20 0.43
NCOA1 Q15788 1/20 0.43
HSD11B1 P28845 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9220428 0.81 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2ACHEHPGDGAA
SCHEMBL8380669 0.80 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2ACHEHPGDGAA
SCHEMBL27438744 0.78 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2ACHEHPGDGAA
SCHEMBL21001982 0.74 ALDH1A1 (0.62) ALDH1A1SMN1; SMN2ACHEHPGDGAA
SCHEMBL7608298 0.74 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2ACHEHPGDGAA
SCHEMBL8778504 0.73 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2ACHEHPGDGAA
SCHEMBL5638260 0.73 ALDH1A1 (0.69) ALDH1A1SMN1; SMN2ACHEHPGDGAA
SCHEMBL30063016 0.72 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2ACHEHPGDCYP1A2
SCHEMBL8778572 0.72 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2ACHEHPGDCYP1A2
SCHEMBL10983933 0.72 ACHE (0.71) ALDH1A1ACHEHPGDKMT2AEPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240190837-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS SYCHRONICITY PHARMA INC (US) 2024-06-13 US disclosed
US-20220411399-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS SYCHRONICITY PHARMA INC (US) 2022-12-29 US disclosed
US-20220411399-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS SYCHRONICITY PHARMA INC (US) 2022-12-29 US disclosed
CN-110003172-B Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators 同步制药公司 2022-04-01 CN disclosed
EP-3939971-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. (US) 2022-01-19 EP disclosed
EP-3939971-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. (US) 2022-01-19 EP disclosed
US-20210171495-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2021-06-10 US disclosed
US-20210171495-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2021-06-10 US disclosed
EP-3129366-B1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS SYNCHRONICITY PHARMA INC (US) 2021-06-09 EP disclosed
EP-3129366-B1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS SYNCHRONICITY PHARMA INC (US) 2021-06-09 EP disclosed
US-10005759-B2 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators RESET THERAPEUTICS, INC. (US) 2018-06-26 US disclosed
US-10005759-B2 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators RESET THERAPEUTICS, INC. (US) 2018-06-26 US disclosed
EP-3129366-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Reset Therapeutics, Inc. (US) 2017-02-15 EP disclosed
WO-2015157182-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS RESET THERAPEUTICS, INC. (US) 2015-10-15 WO disclosed
WO-2015157182-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS RESET THERAPEUTICS, INC. (US) 2015-10-15 WO disclosed
US-20150284362-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2015-10-08 US disclosed
US-20150284362-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2015-10-08 US disclosed
US-20150284362-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2015-10-08 US disclosed
US-20110015198-A1 DIARYLMETHYLAMIDE DERIVATIVE HAVING MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISM BANYU PHARMACEUTICAL CO., INC. 2011-01-20 US disclosed
EP-2272841-A1 DIARYLMETHYLAMIDE DERIVATIVE HAVING ANTAGONISTIC ACTIVITY ON MELANIN-CONCENTRATING HORMONE RECEPTOR Banyu Pharmaceutical Co., Ltd. (JP) 2011-01-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150284362-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS CRY1, CRY2, HCCS ALDH1A1 2882/4885SMN1; SMN2 4746/4885ACHE 1999/4885
US-20210171495-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS CRY1, CRY2, HCCS ALDH1A1 2882/4885SMN1; SMN2 4746/4885ACHE 1999/4885
US-20220411399-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS CRY1, CRY2, HCCS ALDH1A1 2882/4885SMN1; SMN2 4746/4885ACHE 1999/4885
US-10005759-B2 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators CRY1, CRY2, HCCS ALDH1A1 2882/4885SMN1; SMN2 4746/4885ACHE 1999/4885
US-20110015198-A1 DIARYLMETHYLAMIDE DERIVATIVE HAVING MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISM MC1R, MCHR2, MCHR1 ALDH1A1 2052/4885SMN1; SMN2 4140/4885ACHE 4181/4885
US-20240190837-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS CRY1, CRY2, HCCS ALDH1A1 2882/4885SMN1; SMN2 4746/4885ACHE 1999/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.