Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | PLA2G2D | Q9UNK4 | 2/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | BLVRB | P30043 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10030424 | 0.91 | TTR (0.40) | TTRPLA2G2DPTK2BRORCRAB9A | |
| SCHEMBL10030436 | 0.91 | TTR (0.40) | TTRPLA2G2DGRIN2DGRIN2AGRIN2C | |
| SCHEMBL10030409 | 0.89 | PLA2G2D (0.38) | TTRPLA2G2DGRIN2DGRIN2AGRIN2C | |
| SCHEMBL10030444 | 0.87 | SLC22A12 (0.38) | TTRPLA2G2DGRIN2DGRIN2AGRIN2C | |
| SCHEMBL10030438 | 0.87 | CSNK2A2 (0.41) | TTRPLA2G2DGRIN2DGRIN2AGRIN2C | |
| SCHEMBL10030445 | 0.85 | PLA2G2D (0.35) | TTRPLA2G2DGRIN2DGRIN2AGRIN2C | |
| SCHEMBL10030405 | 0.85 | LCK (0.39) | PLAUMEN1KMT2AHTTRAB9A | |
| SCHEMBL10030455 | 0.83 | HTR5A (0.53) | — | |
| SCHEMBL10030447 | 0.82 | GRIN2D (0.43) | PLA2G2DGRIN2DGRIN2AGRIN2CPTPN1 | |
| SCHEMBL10030437 | 0.81 | BCL2L1 (0.46) | TTRPLA2G2DGRIN2DGRIN2AGRIN2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120041036-A1 | SUBSTITUTED ACYLGUANIDINE DERIVATIVES (AS AMENDED) | ASTELLAS PHARMA INC. (JP) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041036-A1 | SUBSTITUTED ACYLGUANIDINE DERIVATIVES (AS AMENDED) | HTR5A, HTR2A, HTR1A | TTR 2555/4885PLA2G2D 1120/4885GRIN2D 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.