Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.40 |
| ▸ | IP6K3 | Q96PC2 | 3/20 | 0.40 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10030437 | 0.87 | BCL2L1 (0.46) | GRIN2DGRIN2AGRIN2CKDM4EHSD17B10 | |
| SCHEMBL10030468 | 0.83 | SLC9A1 (0.42) | — | |
| SCHEMBL10030438 | 0.82 | CSNK2A2 (0.41) | GRIN2DGRIN2AGRIN2CNPC1RAB9A | |
| SCHEMBL10030431 | 0.82 | RAB9A (0.41) | GRIN2DGRIN2AGRIN2CKDM4ESMN1; SMN2 | |
| SCHEMBL10030401 | 0.82 | TTR (0.45) | GRIN2DGRIN2AGRIN2CRAB9APLA2G2D | |
| SCHEMBL10030409 | 0.79 | PLA2G2D (0.38) | GRIN2DGRIN2AGRIN2CKDM4EALDH1A1 | |
| SCHEMBL9448655 | 0.78 | WDR5 (0.56) | GRIN2DGRIN2AGRIN2CCASP3SENP8 | |
| SCHEMBL10030444 | 0.77 | SLC22A12 (0.38) | GRIN2DGRIN2AGRIN2CRAB9APLA2G2D | |
| SCHEMBL10030424 | 0.77 | TTR (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9APLA2G2D | |
| SCHEMBL10030436 | 0.77 | TTR (0.40) | GRIN2DGRIN2AGRIN2CRAB9APLA2G2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120041036-A1 | SUBSTITUTED ACYLGUANIDINE DERIVATIVES (AS AMENDED) | ASTELLAS PHARMA INC. (JP) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041036-A1 | SUBSTITUTED ACYLGUANIDINE DERIVATIVES (AS AMENDED) | HTR5A, HTR2A, HTR1A | GRIN2D 65/4885GRIN2A 33/4885GRIN2C 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.