Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | BLVRB | P30043 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 3/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10030401 | 0.87 | TTR (0.45) | CSNK2A2CSNK2BMAOABLVRBHDAC6 | |
| SCHEMBL10030420 | 0.86 | TTR (0.39) | PLA2G2DTTRACMSDRAB9AMEN1 | |
| SCHEMBL10030426 | 0.85 | NPC1 (0.44) | ADORA3ADORA2AADORA1RAB9AMEN1 | |
| SCHEMBL10030431 | 0.85 | RAB9A (0.41) | PLA2G2DGRIN2DGRIN2AGRIN2CTTR | |
| SCHEMBL10030458 | 0.83 | HTR5A (0.55) | HTR5A | |
| SCHEMBL10030413 | 0.83 | CSNK2A2 (0.41) | CSNK2A2CSNK2BPLA2G2D | |
| SCHEMBL10030447 | 0.82 | GRIN2D (0.43) | PLA2G2DGRIN2DGRIN2AGRIN2CRAB9A | |
| SCHEMBL10030409 | 0.82 | PLA2G2D (0.38) | PLA2G2DGRIN2DGRIN2AGRIN2CTTR | |
| SCHEMBL10030424 | 0.81 | TTR (0.40) | PLA2G2DTTRRAB9APTK2BNPC1 | |
| SCHEMBL10030436 | 0.81 | TTR (0.40) | PLA2G2DGRIN2DGRIN2AGRIN2CTTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120041036-A1 | SUBSTITUTED ACYLGUANIDINE DERIVATIVES (AS AMENDED) | ASTELLAS PHARMA INC. (JP) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041036-A1 | SUBSTITUTED ACYLGUANIDINE DERIVATIVES (AS AMENDED) | HTR5A, HTR2A, HTR1A | CSNK2A2 4150/4885CSNK2B 4524/4885MAOA 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.