Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 4/20 | 0.68 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.68 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.68 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.68 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.52 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.50 |
| ▸ | F9 | P00740 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.48 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.48 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23522710 | 0.85 | CACNA1G (0.72) | PRKAG1PRKAA2PRKAB1PRKAA1CACNA1G | |
| SCHEMBL17513340 | 0.83 | HTT (0.51) | PRKAG1PRKAA2PRKAB1PRKAA1GAA | |
| SCHEMBL10030830 | 0.81 | PRKAG1 (0.54) | PRKAG1PRKAA2PRKAB1PRKAA1CACNA1G | |
| SCHEMBL16176491 | 0.78 | HTT (0.51) | GAAHTTF9SMN1; SMN2LMNA | |
| SCHEMBL2551145 | 0.78 | HTT (0.51) | GAAHTTF9SMN1; SMN2LMNA | |
| SCHEMBL13406081 | 0.77 | TP53 (0.66) | F9SMN1; SMN2LMNATP53 | |
| SCHEMBL13406082 | 0.77 | CTSS (0.62) | SMN1; SMN2LMNATP53 | |
| SCHEMBL31716315 | 0.77 | PRKAG1 (0.72) | PRKAG1PRKAA2PRKAB1PRKAA1CACNA1G | |
| SCHEMBL10454789 | 0.77 | HTT (0.76) | GAAHTTSMN1; SMN2LMNATSHR | |
| SCHEMBL11301498 | 0.76 | SMN1; SMN2 (0.53) | GAAHTTF9SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2987793-B1 | HETEROCYCLIC ACETIC ACID AMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-10-25 | — | — | EP | disclosed |
| US-9708307-B2 | Heterocyclic acetamide compound | ASTELLAS PHARMA INC. (JP) | 2017-07-18 | — | — | US | disclosed |
| EP-2987793-A1 | HETEROCYCLIC ACETIC ACID AMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2016-02-24 | — | — | EP | disclosed |
| US-20150045402-A1 | HETEROCYCLIC ACETAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2015-02-12 | — | — | US | disclosed |
| US-8937087-B2 | Heterocyclic acetamide compound | ASTELLAS PHARMA INC. (JP) | 2015-01-20 | — | — | US | disclosed |
| US-20140315963-A1 | HETEROCYCLIC ACETAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315963-A1 | HETEROCYCLIC ACETAMIDE COMPOUND | DRD1, DRD2, OPRD1 | PRKAG1 318/4885PRKAA2 415/4885PRKAB1 511/4885 |
| US-20150045402-A1 | HETEROCYCLIC ACETAMIDE COMPOUND | DRD2, DRD1, OPRD1 | PRKAG1 269/4885PRKAA2 394/4885PRKAB1 428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.