SCHEMBL10032477

SCHEMBL10032477

Cc1ccc(-c2c3ccccc3c(-c3ccc4ccc(-c5cncc(-c6ccccn6)c5)cc4c3)c3ccccc23)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 2/20 0.40
TP53 P04637 3/20 0.40
PKM P14618 3/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
CYP2A6 P11509 1/20 0.38
CYP11B2 P19099 3/20 0.38
CYP11B1 P15538 2/20 0.38
TGFBR1 P36897 1/20 0.37
CYP17A1 P05093 2/20 0.37
CYP19A1 P11511 1/20 0.37
MAPT P10636 2/20 0.36
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
HSD17B10 Q99714 2/20 0.36
LMNA P02545 1/20 0.36
TSHR P16473 1/20 0.36
KLF5 Q13887 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10032181 0.91 GRM5 (0.44) GRM5CYP2A6CYP11B2CYP11B1TGFBR1
SCHEMBL13015754 0.88 CYP11B1 (0.47) GRM5TP53PKMCYP2A6CYP11B2
SCHEMBL13016100 0.88 KDM4E (0.45) GRM5TP53PKMKMT2ACYP2A6
SCHEMBL10032727 0.87 TRPV1 (0.41) GRM5TP53PKMMEN1KMT2A
SCHEMBL10032734 0.85 CYP2A6 (0.49) CYP2A6CYP11B2CYP11B1CYP17A1CYP19A1
SCHEMBL10032667 0.84 GRM5 (0.41) GRM5TP53PKMMEN1KMT2A
SCHEMBL10032641 0.84 ABL1 (0.40) GRM5TP53PKMCYP2A6CYP11B2
SCHEMBL10032352 0.84 CYP11B2 (0.56) TP53CYP2A6CYP11B2CYP11B1CYP17A1
SCHEMBL10032672 0.84 DHODH (0.41) GRM5TP53PKMMEN1KMT2A
SCHEMBL10032606 0.83 KIF11 (0.41) GRM5TP53PKMCYP2A6CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012060374-A1 ELECTRON TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENCE ELEMENT USING SAME JNC株式会社 (JP) 2012-05-10 WO disclosed